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2004-11-25Habilitation DOI: 10.18452/13949
Genetische und epidemiologische Risikofaktoren für allergische Erkrankungen
dc.contributor.authorNickel, Renate
dc.date.accessioned2017-06-18T00:38:47Z
dc.date.available2017-06-18T00:38:47Z
dc.date.created2004-12-08
dc.date.issued2004-11-25
dc.identifier.urihttp://edoc.hu-berlin.de/18452/14601
dc.description.abstractAsthma, hay fever and atopic dermatitis are complex diseases. Presumably, genetic factors that protected from infectious agents in the past do promote allergic disease in the absence of infectious agents. Linkage and candidate gene studies identified common as well as disease specific genetic determinants of atopic diseases. However, a large number of chromosomal regions and candidate genes were related to asthma and associated traits. International collaborations and meta analyses appear to be mandatory to identify the major genes for asthma and atopy. Also, gene-gene and gene-environment interaction analyses are of great importance to identify genetic risk factors for allergic diseases. Birth cohorts are particularly valuable since exposure to various environmental agents have been documented since early childhood. This work summarizes genetic and epidemiologic studies of the German Multicenter Allergy Study (MAS) that contributed significantly to our understanding of the development of asthma and allergy in childhood. This work summarizes candidate and linkage studies performed in the MAS-cohort and outlines early risk factors for allergic diseases in childhood that were observed in MAS-participants.eng
dc.language.isoger
dc.publisherHumboldt-Universität zu Berlin, Medizinische Fakultät - Universitätsklinikum Charité
dc.rights.urihttp://rightsstatements.org/vocab/InC/1.0/
dc.subjectAsthmager
dc.subjectAllergieger
dc.subjectGenetikger
dc.subjectKohorteger
dc.subjectRisikoger
dc.subjectasthmaeng
dc.subjectallergyeng
dc.subjectgeneticseng
dc.subjectcohorteng
dc.subjectriskeng
dc.subject.ddc610 Medizin und Gesundheit
dc.titleGenetische und epidemiologische Risikofaktoren für allergische Erkrankungen
dc.typedoctoralThesis
dc.identifier.urnurn:nbn:de:kobv:11-10034762
dc.identifier.urnurn:nbn:de:kobv:11-10038611
dc.identifier.urnurn:nbn:de:kobv:11-10038625
dc.identifier.doihttp://dx.doi.org/10.18452/13949
dc.identifier.alephidHU001139199
dc.date.accepted2004-05-17
dc.contributor.refereeSennhaeuser,
dc.contributor.refereeUrbanek,
dc.subject.dnb33 Medizin
dc.subject.rvkYB 3704
dc.subject.rvkYB 5902
dc.subject.rvkYB 5904
dc.subject.rvkYB 6404
local.edoc.pages35
local.edoc.type-nameHabilitation
local.edoc.institutionMedizinische Fakultät - Universitätsklinikum Charité

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