2017-11-17Zeitschriftenartikel DOI: 10.18452/19795
PEGylated Precision Segments Based on Sequence-Defined Thiolactone Oligomers
Du Prez, Filip E.
Börner, Hans G.
A straightforward access route to multifunctional block copolymers, com- bining a poly(ethylene glycol) (PEG) block and a monodisperse segment with discrete monomer sequence based on thiolactone chemistry, is described.Exploiting an inverse conjugation strategy on a PEG preloaded poly(styrene) synthesis resin enables the convenient introduction of a predefined PEG-block at the α-terminus of thiolactone-based sequence-defined oligomers. Reaction conditions for the stepwise, submonomer synthesis at polar solid supports are optimized, using sequential synthesis on a model resin that enables to isolate and determine the purity of the oligomer segments by liquid chroma- tography–electrospray ionization mass spectrometry analysis. The reaction conditions are used to synthesize PEGylated 5mer precision polymers with defined monomer sequence in good yields and high purity to offer an inter- esting platform of macromolecules with potential for biomedical applications.
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