Show simple item record

2017-11-17Zeitschriftenartikel DOI: 10.18452/19795
PEGylated Precision Segments Based on Sequence-Defined Thiolactone Oligomers
dc.contributor.authorCelasun, Sensu
dc.contributor.authorDu Prez, Filip E.
dc.contributor.authorBörner, Hans G.
dc.date.accessioned2019-03-13T12:44:50Z
dc.date.available2019-03-13T12:44:50Z
dc.date.issued2017-11-17none
dc.identifier.issn1521-3927
dc.identifier.other10.1002/marc.201700688
dc.identifier.urihttp://edoc.hu-berlin.de/18452/20592
dc.description.abstractA straightforward access route to multifunctional block copolymers, com- bining a poly(ethylene glycol) (PEG) block and a monodisperse segment with discrete monomer sequence based on thiolactone chemistry, is described.Exploiting an inverse conjugation strategy on a PEG preloaded poly(styrene) synthesis resin enables the convenient introduction of a predefined PEG-block at the α-terminus of thiolactone-based sequence-defined oligomers. Reaction conditions for the stepwise, submonomer synthesis at polar solid supports are optimized, using sequential synthesis on a model resin that enables to isolate and determine the purity of the oligomer segments by liquid chroma- tography–electrospray ionization mass spectrometry analysis. The reaction conditions are used to synthesize PEGylated 5mer precision polymers with defined monomer sequence in good yields and high purity to offer an inter- esting platform of macromolecules with potential for biomedical applications.eng
dc.language.isoengnone
dc.publisherHumboldt-Universität zu Berlin
dc.subject.ddc540 Chemie und zugeordnete Wissenschaftennone
dc.titlePEGylated Precision Segments Based on Sequence-Defined Thiolactone Oligomersnone
dc.typearticle
dc.identifier.urnurn:nbn:de:kobv:11-110-18452/20592-4
dc.identifier.doihttp://dx.doi.org/10.18452/19795
local.edoc.container-titleMacromolecular rapid communicationsnone
local.edoc.pages8none
local.edoc.type-nameZeitschriftenartikel
local.edoc.institutionMathematisch-Naturwissenschaftliche Fakultätnone
local.edoc.container-typeperiodical
local.edoc.container-type-nameZeitschrift
local.edoc.container-publisher-nameWiley VCHnone
local.edoc.container-publisher-placeWeinheimnone
local.edoc.container-volume38none
local.edoc.container-issue24none
local.edoc.container-year2017none
dc.description.versionPeer Reviewednone
local.edoc.container-articlenumber1700688none

Show simple item record