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2017-08-22Zeitschriftenartikel DOI: 10.3390/molecules22081390
The Potential of α-Spinasterol to Mimic the Membrane Properties of Natural Cholesterol
dc.contributor.authorHaralampiev, Ivan
dc.contributor.authorScheidt, Holger A.
dc.contributor.authorHuster, Daniel
dc.contributor.authorMüller, Peter
dc.date.accessioned2019-08-07T12:05:05Z
dc.date.available2019-08-07T12:05:05Z
dc.date.issued2017-08-22none
dc.date.updated2019-07-31T14:29:28Z
dc.identifier.urihttp://edoc.hu-berlin.de/18452/21126
dc.description.abstractSterols play a unique role for the structural and dynamical organization of membranes. The current study reports data on the membrane properties of the phytosterol (3β,5α,22E)-stigmasta-7,22-dien-3-β-ol (α-spinasterol), which represents an important component of argan oil and have not been investigated so far in molecular detail. In particular, the impact of α-spinasterol on the structure and organization of lipid membranes was investigated and compared with those of cholesterol. Various membrane parameters such as the molecular packing of the phospholipid fatty acyl chains, the membrane permeability toward polar molecules, and the formation of lateral membrane domains were studied. The experiments were performed on lipid vesicles using methods of NMR spectroscopy and fluorescence spectroscopy and microscopy. The results show that α-spinasterol resembles the membrane behavior of cholesterol to some degree.eng
dc.language.isoengnone
dc.publisherHumboldt-Universität zu Berlin
dc.rights(CC BY 4.0) Attribution 4.0 Internationalger
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/
dc.subjectcholesteroleng
dc.subjectα-spinasteroleng
dc.subjectmembrane structureeng
dc.subjectmembrane permeabilityeng
dc.subjectlateral domainseng
dc.subjectNMReng
dc.subjectfluorescenceeng
dc.subject.ddc540 Chemie und zugeordnete Wissenschaftennone
dc.titleThe Potential of α-Spinasterol to Mimic the Membrane Properties of Natural Cholesterolnone
dc.typearticle
dc.identifier.urnurn:nbn:de:kobv:11-110-18452/21126-7
dc.identifier.doi10.3390/molecules22081390none
dc.identifier.doihttp://dx.doi.org/10.18452/20371
dc.type.versionpublishedVersionnone
local.edoc.container-titleMoleculesnone
local.edoc.pages11none
local.edoc.type-nameZeitschriftenartikel
local.edoc.institutionLebenswissenschaftliche Fakultätnone
local.edoc.container-typeperiodical
local.edoc.container-type-nameZeitschrift
local.edoc.container-publisher-nameMDPInone
local.edoc.container-publisher-placeBaselnone
local.edoc.container-volume22none
local.edoc.container-issue8none
local.edoc.container-firstpage1390/1none
local.edoc.container-lastpage1390/11none
dc.description.versionPeer Reviewednone
dc.identifier.eissn1420-3049
local.edoc.affiliationHaralampiev, Ivan; Department of Biology, Humboldt-Universität zu Berlin, Invalidenstr. 42, D-10115 Berlin, Germany,none
local.edoc.affiliationScheidt, Holger A.; Institute for Medical Physics and Biophysics, Leipzig University, Härtelstr. 16−18, D-04107 Leipzig, Germany,none
local.edoc.affiliationHuster, Daniel; Institute for Medical Physics and Biophysics, Leipzig University, Härtelstr. 16−18, D-04107 Leipzig, Germany,none
local.edoc.affiliationMüller, Peter; Department of Biology, Humboldt-Universität zu Berlin, Invalidenstr. 42, D-10115 Berlin, Germany,none

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