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2012-05-03Zeitschriftenartikel DOI: 10.18452/20742
Prognostic Significance of Circulating Levels of Hepatocyte Growth Factor in Patients with Chagas’ Disease and Idiopathic Dilated Cardiomyopathy
dc.contributor.authorWang, Yong
dc.contributor.authorMoreira, Maria da Consolação V.
dc.contributor.authorKhan, Adnan
dc.contributor.authorHeringer-Walther, Silvia
dc.contributor.authorSchultheiss, Heinz-Peter
dc.contributor.authorWessel, Niels
dc.contributor.authorSiems, Wolf-Eberhard
dc.contributor.authorWalther, Thomas
dc.contributor.authorWalther, Thomas
dc.date.accessioned2019-11-12T11:12:00Z
dc.date.available2019-11-12T11:12:00Z
dc.date.issued2012-05-03none
dc.date.updated2019-09-23T13:51:29Z
dc.identifier.issn0008-6312
dc.identifier.urihttp://edoc.hu-berlin.de/18452/21481
dc.descriptionThis publication is with permission of the rights owner freely accessible due to an alliance licence and a national licence (funded by the DFG, German Research Foundation) respectively.none
dc.description.abstractObjectives: Hepatocyte growth factor (HGF) plays an important role in the improvement in cardiac function and remodeling in a variety of cardiovascular diseases. It is also a strong predictor of mortality in some heart failure (HF) patients. However, its prognostic value in patients with Chagas’ disease (CD) or idiopathic dilated cardiomyopathy (DCM) remains to be investigated. Methods and Results: In this prospective cohort study, HGF concentrations were measured in patients with CD (n = 91), DCM (n = 47), and control subjects (n = 25). While no difference was detected for patients with New York Heart Association class I–II, HGF was significantly increased in advanced HF patients (New York Heart Association class III–IV) in both CD and DCM groups, compared with healthy subjects. There was a strong correlation between HGF and left ventricular ejection fraction in CD patients. However, there was no correlation in patients with DCM. Despite its strong correlation with left ventricular ejection fraction in CD patients, HGF failed to predict mortality and necessity for heart transplant in both CD and DCM patients. Conclusions: Although HGF can be significantly increased in advanced HF patients with CD and DCM, its prognostic value for endpoints is minor. Therefore, the formerly described predictive power for HGF in HF might be restricted to specific etiologies of HF.eng
dc.language.isoengnone
dc.publisherHumboldt-Universität zu Berlin
dc.rights.urihttp://rightsstatements.org/vocab/InC/1.0/
dc.subjectChagas’ diseaseeng
dc.subjectDilated cardiomyopathyeng
dc.subjectHeart failureeng
dc.subjectHepatocyte growth factoreng
dc.subject.ddc610 Medizin und Gesundheitnone
dc.titlePrognostic Significance of Circulating Levels of Hepatocyte Growth Factor in Patients with Chagas’ Disease and Idiopathic Dilated Cardiomyopathynone
dc.typearticle
dc.identifier.urnurn:nbn:de:kobv:11-110-18452/21481-0
dc.identifier.doihttp://dx.doi.org/10.18452/20742
dc.type.versionpublishedVersionnone
local.edoc.pages7none
local.edoc.type-nameZeitschriftenartikel
local.edoc.container-typeperiodical
local.edoc.container-type-nameZeitschrift
dc.description.versionPeer Reviewednone
dc.identifier.eissn1421-9751
dcterms.bibliographicCitation.doi10.1159/000337080none
dcterms.bibliographicCitation.pmid22555361
dcterms.bibliographicCitation.journaltitleCardiologynone
dcterms.bibliographicCitation.volume121none
dcterms.bibliographicCitation.issue4none
dcterms.bibliographicCitation.originalpublishernameS. Karger AGnone
dcterms.bibliographicCitation.originalpublisherplaceBaselnone
dcterms.bibliographicCitation.pagestart240none
dcterms.bibliographicCitation.pageend246none
bua.import.affiliationWang, Yong; Department of Experimental Cardiology, Excellence Cluster Cardio-Pulmonary System, Justus-Liebig University, Giessennone
bua.import.affiliationMoreira, Maria da Consolação V.; Department of Internal Medicine, Federal University of Minas Gerais, Belo Horizontenone
bua.import.affiliationKhan, Adnan; Department of Experimental Cardiology, Excellence Cluster Cardio-Pulmonary System, Justus-Liebig University, Giessennone
bua.import.affiliationHeringer-Walther, Silvia; Instituto Metropolitano de Ensino Superior/Univaço, Ipatinga, Brazilnone
bua.import.affiliationSchultheiss, Heinz-Peter; Department of Cardiology, Charité, Campus Benjamin Franklinnone
bua.import.affiliationWessel, Niels; Department of Physics, Humboldt Universität zu Berlinnone
bua.import.affiliationSiems, Wolf-Eberhard; Leibniz Institute of Molecular Pharmacology, Berlin, Germanynone
bua.import.affiliationWalther, Thomas; Department of Experimental Cardiology, Excellence Cluster Cardio-Pulmonary System, Justus-Liebig University, Giessen; Centre for Cardiovascular and Metabolic Research, Hull York Medical School, University of Hull, Hull, UKnone
bua.departmentMathematisch-Naturwissenschaftliche Fakultätnone

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