Sphingolipid-Transporting Proteins as Cancer Therapeutic Targets
dc.contributor.author | Samaha, Doaa | |
dc.contributor.author | Hamdo, Housam H. | |
dc.contributor.author | Wilde, Max | |
dc.contributor.author | Prause, Kevin | |
dc.contributor.author | Arenz, Christoph | |
dc.date.accessioned | 2019-11-12T16:09:03Z | |
dc.date.available | 2019-11-12T16:09:03Z | |
dc.date.issued | 2019-07-20 | none |
dc.identifier.uri | http://edoc.hu-berlin.de/18452/21486 | |
dc.description | This article was supported by the German Research Foundation (DFG) and the Open Access Publication Fund of Humboldt-Universität zu Berlin. | none |
dc.description.abstract | The understanding of the role of sphingolipid metabolism in cancer has tremendously increased in the past ten years. Many tumors are characterized by imbalances in sphingolipid metabolism. In many cases, disorders of sphingolipid metabolism are also likely to cause or at least promote cancer. In this review, sphingolipid transport proteins and the processes catalyzed by them are regarded as essential components of sphingolipid metabolism. There is much to suggest that these processes are often rate-limiting steps for metabolism of individual sphingolipid species and thus represent potential target structures for pharmaceutical anticancer research. Here, we summarize empirical and biochemical data on different proteins with key roles in sphingolipid transport and their potential role in cancer. | eng |
dc.language.iso | eng | none |
dc.publisher | Humboldt-Universität zu Berlin | |
dc.rights | (CC BY 4.0) Attribution 4.0 International | ger |
dc.rights.uri | https://creativecommons.org/licenses/by/4.0/ | |
dc.subject | lipid transfer proteins | eng |
dc.subject | sphingolipids | eng |
dc.subject | lipid trafficking | eng |
dc.subject | sphingolipid transporters | eng |
dc.subject | transport inhibitors | eng |
dc.subject.ddc | 540 Chemie und zugeordnete Wissenschaften | none |
dc.title | Sphingolipid-Transporting Proteins as Cancer Therapeutic Targets | none |
dc.type | article | |
dc.identifier.urn | urn:nbn:de:kobv:11-110-18452/21486-9 | |
dc.identifier.doi | http://dx.doi.org/10.18452/20747 | |
dc.type.version | publishedVersion | none |
local.edoc.pages | 15 | none |
local.edoc.type-name | Zeitschriftenartikel | |
local.edoc.container-type | periodical | |
local.edoc.container-type-name | Zeitschrift | |
dc.description.version | Peer Reviewed | none |
dc.identifier.eissn | 1422-0067 | |
dcterms.bibliographicCitation.doi | 10.3390/ijms20143554 | |
dcterms.bibliographicCitation.journaltitle | International journal of molecular sciences | none |
dcterms.bibliographicCitation.volume | 20 | none |
dcterms.bibliographicCitation.issue | 14 | none |
dcterms.bibliographicCitation.articlenumber | 3554 | |
dcterms.bibliographicCitation.originalpublishername | Molecular Diversity Preservation International (MDPI) | none |
dcterms.bibliographicCitation.originalpublisherplace | Basel | none |
bua.department | Mathematisch-Naturwissenschaftliche Fakultät | none |
dcterms.bibliographicCitation.journalparttitle | Lipid as a Cancer Therapeutic Target |