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2014-10-30Zeitschriftenartikel DOI: 10.1159/000362840
Model-Based and Model-Free Decisions in Alcohol Dependence
Sebold, Miriam cc
Deserno, Lorenz cc
Nebe, Stephan cc
Schad, Daniel cc
Garbusow, Maria
Hägele, Claudia
Keller, Jürgen
Jünger, Elisabeth
Kathmann, Norbert cc
Smolka, Michael
Rapp, Michael cc
Schlagenhauf, Florian cc
Heinz, Andreas cc
Huys, Quentin cc
Lebenswissenschaftliche Fakultät
Background: Human and animal work suggests a shift from goal-directed to habitual decision-making in addiction. However, the evidence for this in human alcohol dependence is as yet inconclusive. Methods: Twenty-six healthy controls and 26 recently detoxified alcohol-dependent patients underwent behavioral testing with a 2-step task designed to disentangle goal-directed and habitual response patterns. Results: Alcohol-dependent patients showed less evidence of goal-directed choices than healthy controls, particularly after losses. There was no difference in the strength of the habitual component. The group differences did not survive controlling for performance on the Digit Symbol Substitution Task. Conclusion: Chronic alcohol use appears to selectively impair goal-directed function, rather than promoting habitual responding. It appears to do so particularly after nonrewards, and this may be mediated by the effects of alcohol on more general cognitive functions subserved by the prefrontal cortex.
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This publication is with permission of the rights owner freely accessible due to an alliance licence and a national licence (funded by the DFG, German Research Foundation) respectively.
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DOI
10.1159/000362840
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https://doi.org/10.1159/000362840
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<a href="https://doi.org/10.1159/000362840">https://doi.org/10.1159/000362840</a>