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2014-04-29Zeitschriftenartikel DOI: 10.18452/20826
Genetic variation of the RASGRF1 regulatory region affects human hippocampus-dependent memory
dc.contributor.authorBarman, Adriana
dc.contributor.authorAssmann, Anne
dc.contributor.authorRichter, Sylvia
dc.contributor.authorSoch, Joram
dc.contributor.authorSchütze, Hartmut
dc.contributor.authorWüstenberg, Torsten
dc.contributor.authorDeibele, Anna
dc.contributor.authorKlein, Marieke
dc.contributor.authorRichter, Anni
dc.contributor.authorBehnisch, Gusalija
dc.contributor.authorDüzel, Emrah
dc.contributor.authorZenker, Martin
dc.contributor.authorSeidenbecher, Constanze I.
dc.contributor.authorSchott, Björn H
dc.date.accessioned2019-11-26T09:42:00Z
dc.date.available2019-11-26T09:42:00Z
dc.date.issued2014-04-29none
dc.date.updated2019-09-27T09:35:33Z
dc.identifier.urihttp://edoc.hu-berlin.de/18452/21561
dc.description.abstractThe guanine nucleotide exchange factor RASGRF1 is an important regulator of intracellular signaling and neural plasticity in the brain. RASGRF1-deficient mice exhibit a complex phenotype with learning deficits and ocular abnormalities. Also in humans, a genome-wide association study has identified the single nucleotide polymorphism (SNP) rs8027411 in the putative transcription regulatory region of RASGRF1 as a risk variant of myopia. Here we aimed to assess whether, in line with the RASGRF1 knockout mouse phenotype, rs8027411 might also be associated with human memory function. We performed computer-based neuropsychological learning experiments in two independent cohorts of young, healthy participants. Tests included the Verbal Learning and Memory Test (VLMT) and the logical memory section of the Wechsler Memory Scale (WMS). Two sub-cohorts additionally participated in functional magnetic resonance imaging (fMRI) studies of hippocampus function. 119 participants performed a novelty encoding task that had previously been shown to engage the hippocampus, and 63 subjects participated in a reward-related memory encoding study. RASGRF1 rs8027411 genotype was indeed associated with memory performance in an allele dosage-dependent manner, with carriers of the T allele (i.e., the myopia risk allele) showing better memory performance in the early encoding phase of the VLMT and in the recall phase of the WMS logical memory section. In fMRI, T allele carriers exhibited increased hippocampal activation during presentation of novel images and during encoding of pictures associated with monetary reward. Taken together, our results provide evidence for a role of the RASGRF1 gene locus in hippocampus-dependent memory and, along with the previous association with myopia, point toward pleitropic effects of RASGRF1 genetic variations on complex neural function in humans.eng
dc.language.isoengnone
dc.publisherHumboldt-Universität zu Berlin
dc.rights(CC BY 3.0) Attribution 3.0 Unportedger
dc.rights.urihttp://creativecommons.org/licenses/by/3.0/
dc.subjectRASGRF1eng
dc.subjecthippocampuseng
dc.subjectepisodic memoryeng
dc.subjectgenetic variationeng
dc.subjectfMRIeng
dc.subject.ddc610 Medizin und Gesundheitnone
dc.titleGenetic variation of the RASGRF1 regulatory region affects human hippocampus-dependent memorynone
dc.typearticle
dc.identifier.urnurn:nbn:de:kobv:11-110-18452/21561-4
dc.identifier.doihttp://dx.doi.org/10.18452/20826
dc.type.versionpublishedVersionnone
local.edoc.pages12none
local.edoc.type-nameZeitschriftenartikel
local.edoc.container-typeperiodical
local.edoc.container-type-nameZeitschrift
dc.description.versionPeer Reviewednone
dc.identifier.eissn1662-5161
dcterms.bibliographicCitation.doi10.3389/fnhum.2014.00260none
dcterms.bibliographicCitation.journaltitleFrontiers in human neurosciencenone
dcterms.bibliographicCitation.volume8none
dcterms.bibliographicCitation.articlenumber260
dcterms.bibliographicCitation.originalpublishernameFrontiers Media S.A.none
dcterms.bibliographicCitation.originalpublisherplaceLausannenone
bua.departmentHumboldt-Universität (insgesamt)none

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