Show simple item record

2017-05-31Zeitschriftenartikel DOI: 10.3389/fcimb.2017.00198
Engineering of Genetically Arrested Parasites (GAPs) For a Precision Malaria Vaccine
dc.contributor.authorKreutzfeld, Oriana
dc.contributor.authorMüller, Katja
dc.contributor.authorMatuschewski, Kai
dc.date.accessioned2019-11-26T15:15:50Z
dc.date.available2019-11-26T15:15:50Z
dc.date.issued2017-05-31none
dc.date.updated2019-09-27T11:16:38Z
dc.identifier.urihttp://edoc.hu-berlin.de/18452/21571
dc.description.abstractContinuous stage conversion and swift changes in the antigenic repertoire in response to acquired immunity are hallmarks of complex eukaryotic pathogens, including Plasmodium species, the causative agents of malaria. Efficient elimination of Plasmodium liver stages prior to blood infection is one of the most promising malaria vaccine strategies. Here, we describe different genetically arrested parasites (GAPs) that have been engineered in Plasmodium berghei, P. yoelii and P. falciparum and compare their vaccine potential. A better understanding of the immunological mechanisms of prime and boost by arrested sporozoites and experimental strategies to enhance vaccine efficacy by further engineering existing GAPs into a more immunogenic form hold promise for continuous improvements of GAP-based vaccines. A critical hurdle for vaccines that elicit long-lasting protection against malaria, such as GAPs, is safety and efficacy in vulnerable populations. Vaccine research should focus on solutions toward turning malaria into a vaccine-preventable disease, which would offer an exciting new path of malaria control.eng
dc.language.isoengnone
dc.publisherHumboldt-Universität zu Berlin
dc.rights(CC BY 4.0) Attribution 4.0 Internationalger
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/
dc.subjectmalariaeng
dc.subjectPlasmodiumeng
dc.subjectvaccineeng
dc.subjectliver stageeng
dc.subjectlive attenuated parasiteeng
dc.subjectsporozoiteeng
dc.subjectimmune memoryeng
dc.subject.ddc610 Medizin und Gesundheitnone
dc.titleEngineering of Genetically Arrested Parasites (GAPs) For a Precision Malaria Vaccinenone
dc.typearticle
dc.identifier.urnurn:nbn:de:kobv:11-110-18452/21571-0
dc.identifier.doi10.3389/fcimb.2017.00198none
dc.identifier.doihttp://dx.doi.org/10.18452/20835
dc.type.versionpublishedVersionnone
local.edoc.container-titleFrontiers in Cellular and Infection Microbiologynone
local.edoc.pages13none
local.edoc.type-nameZeitschriftenartikel
local.edoc.institutionLebenswissenschaftliche Fakultätnone
local.edoc.container-typeperiodical
local.edoc.container-type-nameZeitschrift
local.edoc.container-publisher-nameFrontiers Media S.A.none
local.edoc.container-publisher-placeLausannenone
local.edoc.container-volume7none
dc.description.versionPeer Reviewednone
local.edoc.container-articlenumber198
dc.identifier.eissn2235-2988

Show simple item record