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2016-04-19Zeitschriftenartikel DOI: 10.18452/20860
Working Memory Network Changes in ALS
dc.contributor.authorVellage, Anne-Katrin
dc.contributor.authorVeit, Maria
dc.contributor.authorKobeleva, Xenia
dc.contributor.authorPetri, Susanne
dc.contributor.authorVielhaber, Stefan
dc.contributor.authorMüller, Notger G.
dc.date.accessioned2019-11-29T12:50:23Z
dc.date.available2019-11-29T12:50:23Z
dc.date.issued2016-04-19none
dc.date.updated2019-09-30T22:33:36Z
dc.identifier.urihttp://edoc.hu-berlin.de/18452/21596
dc.description.abstractWe used amyotrophic lateral sclerosis (ALS) as a model of prefrontal dysfunction in order to re-assess the potential neuronal substrates of two sub processes of working memory, namely information storage and filtering. To date it is unclear which exact neuronal networks sustain these two processes and the prefrontal cortex was suggested to play a crucial role both for filtering out of irrelevant information and for the storage of relevant information in memory. Other research has attributed information storage to more posterior brain regions, including the parietal cortex and stressed the role of subcortical areas in information filtering. We studied 14 patients suffering from ALS and the same number of healthy controls in an fMRI-task that allowed calculating separate storage and filtering scores. A brain volume analysis confirmed prefrontal atrophy in the patient group. Regarding their performance in the working memory task, we observed a trend toward slightly impaired storage capabilities whereas filtering appeared completely intact. Despite the rather subtle behavioral deficits we observed marked changes in neuronal activity associated with ALS: Compared to healthy controls patients showed significantly reduced hemodynamic responses in the left occipital cortex and right prefrontal cortex in the storage contrast. The filter contrast on the other hand revealed a relative hyperactivation in the superior frontal gyrus of the ALS patients. This hyperactivation might reflect a possible compensational mechanism for the prefrontal degeneration found in ALS. The reduced hemodynamic responses in the storage contrast might reflect a disruption of prefrontal top-down control of posterior brain regions, a process which was especially relevant in the most difficult high load memory task. Taken together, the present study demonstrates marked neurophysiological changes in ALS patients compared to healthy controls during the filtering and storage of information in spite of largely intact behavior. With respect to the neuronal substrates of the two working memory processes under investigation here, the results suggest that it is rather the degree to which top-down control is required for task completion that determines prefrontal cortex involvement than the specific nature of the process, i.e., storage vs. filtering.eng
dc.language.isoengnone
dc.publisherHumboldt-Universität zu Berlin
dc.rights(CC BY 4.0) Attribution 4.0 Internationalger
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/
dc.subjectworking memoryeng
dc.subjectfMRIeng
dc.subjectALSeng
dc.subjectprefrontal cortexeng
dc.subjectselective attentioneng
dc.subject.ddc610 Medizin und Gesundheitnone
dc.titleWorking Memory Network Changes in ALSnone
dc.typearticle
dc.identifier.urnurn:nbn:de:kobv:11-110-18452/21596-4
dc.identifier.doihttp://dx.doi.org/10.18452/20860
dc.type.versionpublishedVersionnone
local.edoc.pages10none
local.edoc.type-nameZeitschriftenartikel
local.edoc.container-typeperiodical
local.edoc.container-type-nameZeitschrift
dc.description.versionPeer Reviewednone
dc.identifier.eissn1662-453X
dc.title.subtitleAn fMRI Studynone
dcterms.bibliographicCitation.doi10.3389/fnins.2016.00158none
dcterms.bibliographicCitation.journaltitleFrontiers in neurosciencenone
dcterms.bibliographicCitation.volume10none
dcterms.bibliographicCitation.articlenumber158
dcterms.bibliographicCitation.originalpublishernameFrontiers Media S.A.none
dcterms.bibliographicCitation.originalpublisherplaceLausannenone
bua.departmentHumboldt-Universität (insgesamt)none

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