Show simple item record

2012-04-05Zeitschriftenartikel DOI: 10.3389/fgene.2012.00048
Meta-Analysis of Global Transcriptomics Suggests that Conserved Genetic Pathways are Responsible for Quercetin and Tannic Acid Mediated Longevity in C. elegans
dc.contributor.authorPietsch, Kerstin
dc.contributor.authorSaul, Nadine
dc.contributor.authorSwain, Suresh C.
dc.contributor.authorMenzel, Ralph
dc.contributor.authorSteinberg, Christian E.W.
dc.contributor.authorStürzenbaum, Stephen R.
dc.date.accessioned2019-12-10T12:17:38Z
dc.date.available2019-12-10T12:17:38Z
dc.date.issued2012-04-05none
dc.date.updated2019-10-07T11:47:40Z
dc.identifier.urihttp://edoc.hu-berlin.de/18452/21621
dc.description.abstractRecent research has highlighted that the polyphenols Quercetin and Tannic acid are capable of extending the lifespan of Caenorhabditis elegans. To gain a deep understanding of the underlying molecular genetics, we analyzed the global transcriptional patterns of nematodes exposed to three concentrations of Quercetin or Tannic acid, respectively. By means of an intricate meta-analysis it was possible to compare the transcriptomes of polyphenol exposure to recently published datasets derived from (i) longevity mutants or (ii) infection. This detailed comparative in silico analysis facilitated the identification of compound specific and overlapping transcriptional profiles and allowed the prediction of putative mechanistic models of Quercetin and Tannic acid mediated longevity. Lifespan extension due to Quercetin was predominantly driven by the metabolome, TGF-beta signaling, Insulin-like signaling, and the p38 MAPK pathway and Tannic acid’s impact involved, in part, the amino acid metabolism and was modulated by the TGF-beta and the p38 MAPK pathways. DAF-12, which integrates TGF-beta and Insulin-like downstream signaling, and genetic players of the p38 MAPK pathway therefore seem to be crucial regulators for both polyphenols. Taken together, this study underlines how meta-analyses can provide an insight of molecular events that go beyond the traditional categorization into gene ontology-terms and Kyoto encyclopedia of genes and genomes-pathways. It also supports the call to expand the generation of comparative and integrative databases, an effort that is currently still in its infancy.eng
dc.language.isoengnone
dc.publisherHumboldt-Universität zu Berlin
dc.rights(CC BY-NC 3.0) Attribution-NonCommercial 3.0 Unportedger
dc.rights.urihttps://creativecommons.org/licenses/by-nc/3.0/
dc.subjectQuercetineng
dc.subjectTannic acideng
dc.subjectTGF-betaeng
dc.subjectILSeng
dc.subjectDAF-12eng
dc.subjectp38 MAPKeng
dc.subjectC. eleganseng
dc.subject.ddc570 Biologienone
dc.titleMeta-Analysis of Global Transcriptomics Suggests that Conserved Genetic Pathways are Responsible for Quercetin and Tannic Acid Mediated Longevity in C. elegansnone
dc.typearticle
dc.identifier.urnurn:nbn:de:kobv:11-110-18452/21621-6
dc.identifier.doi10.3389/fgene.2012.00048none
dc.identifier.doihttp://dx.doi.org/10.18452/20906
dc.type.versionpublishedVersionnone
local.edoc.container-titleFrontiers in Geneticsnone
local.edoc.pages11none
local.edoc.type-nameZeitschriftenartikel
local.edoc.institutionLebenswissenschaftliche Fakultätnone
local.edoc.container-typeperiodical
local.edoc.container-type-nameZeitschrift
local.edoc.container-publisher-nameFrontiers Research Foundationnone
local.edoc.container-publisher-placeLausannenone
local.edoc.container-volume3none
dc.description.versionPeer Reviewednone
local.edoc.container-articlenumber48none
dc.identifier.eissn1664-8021

Show simple item record