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2018-08-23Zeitschriftenartikel DOI: 10.3389/fphys.2018.01178
Systematic Analysis of Mouse Genome Reveals Distinct Evolutionary and Functional Properties Among Circadian and Ultradian Genes
dc.contributor.authorCastellana, Stefano
dc.contributor.authorMazza, Tommaso
dc.contributor.authorCapocefalo, Daniele
dc.contributor.authorGenov, Nikolai
dc.contributor.authorBiagini, Tommaso
dc.contributor.authorFusilli, Caterina
dc.contributor.authorScholkmann, Felix
dc.contributor.authorRelógio, Angela
dc.contributor.authorHogenesch, John B.
dc.contributor.authorMazzoccoli, Gianluigi Ubaldo
dc.date.accessioned2019-12-17T11:52:00Z
dc.date.available2019-12-17T11:52:00Z
dc.date.issued2018-08-23none
dc.date.updated2019-10-08T15:09:39Z
dc.identifier.urihttp://edoc.hu-berlin.de/18452/21706
dc.description.abstractIn living organisms, biological clocks regulate 24 h (circadian) molecular, physiological, and behavioral rhythms to maintain homeostasis and synchrony with predictable environmental changes, in particular with those induced by Earth’s rotation on its axis. Harmonics of these circadian rhythms having periods of 8 and 12 h (ultradian) have been documented in several species. In mouse liver, harmonics of the 24-h period of gene transcription hallmarked genes oscillating with a frequency two or three times faster than circadian periodicity. Many of these harmonic transcripts enriched pathways regulating responses to environmental stress and coinciding preferentially with subjective dawn and dusk. At this time, the evolutionary history of genes with rhythmic expression is still poorly known and the role of length-of-day changes due to Earth’s rotation speed decrease over the last four billion years is totally ignored. We hypothesized that ultradian and stress anticipatory genes would be more evolutionarily conserved than circadian genes and background non-oscillating genes. To investigate this issue, we performed broad computational analyses of genes/proteins oscillating at different frequency ranges across several species and showed that ultradian genes/proteins, especially those oscillating with a 12-h periodicity, are more likely to be of ancient origin and essential in mice. In summary, our results show that genes with ultradian transcriptional patterns are more likely to be phylogenetically conserved and associated with the primeval and inevitable dawn/dusk transitions.eng
dc.language.isoengnone
dc.publisherHumboldt-Universität zu Berlin
dc.rights(CC BY 4.0) Attribution 4.0 Internationalger
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/
dc.subjectclockeng
dc.subjectgeneeng
dc.subjectevolutioneng
dc.subjectrhythmicityeng
dc.subjectcircadianeng
dc.subjectultradianeng
dc.subject.ddc610 Medizin und Gesundheitnone
dc.titleSystematic Analysis of Mouse Genome Reveals Distinct Evolutionary and Functional Properties Among Circadian and Ultradian Genesnone
dc.typearticle
dc.identifier.urnurn:nbn:de:kobv:11-110-18452/21706-0
dc.identifier.doi10.3389/fphys.2018.01178none
dc.identifier.doihttp://dx.doi.org/10.18452/20954
dc.type.versionpublishedVersionnone
local.edoc.container-titleFrontiers in Physiologynone
local.edoc.pages12none
local.edoc.type-nameZeitschriftenartikel
local.edoc.institutionLebenswissenschaftliche Fakultätnone
local.edoc.container-typeperiodical
local.edoc.container-type-nameZeitschrift
local.edoc.container-publisher-nameFrontiers Media S.A.none
local.edoc.container-publisher-placeLausannenone
local.edoc.container-volume9none
dc.description.versionPeer Reviewednone
local.edoc.container-articlenumber1178none
dc.identifier.eissn1664-042X

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