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2019-04-05Zeitschriftenartikel DOI: 10.3389/fncom.2019.00019
Bistable Firing Pattern in a Neural Network Model
dc.contributor.authorProtachevicz, Paulo
dc.contributor.authorBorges, Fernando S.
dc.contributor.authorLameu, Ewandson Luiz
dc.contributor.authorJi, Peng
dc.contributor.authorIarosz, Kelly
dc.contributor.authorKihara, Alexandre
dc.contributor.authorCaldas, Ibere
dc.contributor.authorSzezech, Jose Danilo
dc.contributor.authorBaptista, Murilo
dc.contributor.authorMacau, Elbert Einstein Nehrer
dc.contributor.authorAntonopoulos, Chris
dc.contributor.authorBatista, Antonio M.
dc.contributor.authorKurths, Jürgen
dc.date.accessioned2019-12-17T13:02:05Z
dc.date.available2019-12-17T13:02:05Z
dc.date.issued2019-04-05none
dc.date.updated2019-10-08T21:28:06Z
dc.identifier.urihttp://edoc.hu-berlin.de/18452/21708
dc.description.abstractExcessively high, neural synchronization has been associated with epileptic seizures, one of the most common brain diseases worldwide. A better understanding of neural synchronization mechanisms can thus help control or even treat epilepsy. In this paper, we study neural synchronization in a random network where nodes are neurons with excitatory and inhibitory synapses, and neural activity for each node is provided by the adaptive exponential integrate-and-fire model. In this framework, we verify that the decrease in the influence of inhibition can generate synchronization originating from a pattern of desynchronized spikes. The transition from desynchronous spikes to synchronous bursts of activity, induced by varying the synaptic coupling, emerges in a hysteresis loop due to bistability where abnormal (excessively high synchronous) regimes exist. We verify that, for parameters in the bistability regime, a square current pulse can trigger excessively high (abnormal) synchronization, a process that can reproduce features of epileptic seizures. Then, we show that it is possible to suppress such abnormal synchronization by applying a small-amplitude external current on > 10% of the neurons in the network. Our results demonstrate that external electrical stimulation not only can trigger synchronous behavior, but more importantly, it can be used as a means to reduce abnormal synchronization and thus, control or treat effectively epileptic seizures.eng
dc.language.isoengnone
dc.publisherHumboldt-Universität zu Berlin
dc.rights(CC BY 4.0) Attribution 4.0 Internationalger
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/
dc.subjectbistable regimeeng
dc.subjectnetworkeng
dc.subjectadaptive exponential integrate-and-fire neural modeleng
dc.subjectneural dynamicseng
dc.subjectsynchronizationeng
dc.subjectepilepsyeng
dc.subject.ddc610 Medizin und Gesundheitnone
dc.titleBistable Firing Pattern in a Neural Network Modelnone
dc.typearticle
dc.identifier.urnurn:nbn:de:kobv:11-110-18452/21708-2
dc.identifier.doi10.3389/fncom.2019.00019none
dc.identifier.doihttp://dx.doi.org/10.18452/20957
dc.type.versionpublishedVersionnone
local.edoc.container-titleFrontiers in Computational Neurosciencenone
local.edoc.pages8none
local.edoc.type-nameZeitschriftenartikel
local.edoc.institutionMathematisch-Naturwissenschaftliche Fakultätnone
local.edoc.container-typeperiodical
local.edoc.container-type-nameZeitschrift
local.edoc.container-publisher-nameFrontiers Media S.A.none
local.edoc.container-publisher-placeLausannenone
local.edoc.container-volume13none
dc.description.versionPeer Reviewednone
local.edoc.container-articlenumber19none
dc.identifier.eissn1662-5188

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