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2020-01-15Zeitschriftenartikel DOI: 10.18452/21068
Peptide-Assisted Design of Precision Polymer Sequences
dc.contributor.authorCelasun, Sensu
dc.contributor.authorMaron, Eva
dc.contributor.authorBörner, Hans G.
dc.date.accessioned2020-01-22T09:32:27Z
dc.date.available2020-01-22T09:32:27Z
dc.date.issued2020-01-15none
dc.identifier.other10.1002/mabi.201900244
dc.identifier.urihttp://edoc.hu-berlin.de/18452/21816
dc.description.abstractFunctional sequences of monodisperse, sequence‐defined oligo(amide‐urethane)s are designed based on a peptide sequence as blueprint. The translation of a discrete side‐chain functionality sequence from a known peptide‐based solubilizer of the photosensitizer meta‐tetra(hydroxyphenyl)‐chlorin, into a non‐peptidic precision polymer backbone is demonstrated. The resulting peptidomimetic precision polymers retain the functions of the parent peptide sequence, showing analogues sensitivity toward single monomer mutations/exchanges and even exceeding the parent peptide equivalent by reaching up to 69% higher payload capacities and more favored release kinetics.eng
dc.language.isoengnone
dc.publisherHumboldt-Universität zu Berlin
dc.rights(CC BY 4.0) Attribution 4.0 Internationalger
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/
dc.subject.ddc570 Biowissenschaften; Biologienone
dc.titlePeptide-Assisted Design of Precision Polymer Sequencesnone
dc.typearticle
dc.subtitleOn the Relevance of the Side-Chain Sequences and the Variability of the Backbonenone
dc.identifier.urnurn:nbn:de:kobv:11-110-18452/21816-1
dc.identifier.doihttp://dx.doi.org/10.18452/21068
dc.type.versionpublishedVersionnone
local.edoc.container-titleMacromolecular biosciencenone
local.edoc.pages6none
local.edoc.type-nameZeitschriftenartikel
local.edoc.institutionMathematisch-Naturwissenschaftliche Fakultätnone
local.edoc.container-typeperiodical
local.edoc.container-type-nameZeitschrift
local.edoc.container-publisher-nameWiley-VCHnone
local.edoc.container-publisher-placeWeinheimnone
local.edoc.container-volume20none
local.edoc.container-issue1none
dc.description.versionPeer Reviewednone
local.edoc.container-articlenumber1900244none
dc.identifier.eissn1616-5195

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