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2020-02-07Zeitschriftenartikel DOI: 10.18452/21201
Clusters of cooperative ion channels enable a membrane-potential-based mechanism for short-term memory
dc.contributor.authorPfeiffer, Paul
dc.contributor.authorEgorov, Alexei
dc.contributor.authorLorenz, Franziska
dc.contributor.authorSchleimer, Jan Hendrik
dc.contributor.authorDraguhn, Andreas
dc.contributor.authorSchreiber, Susanne
dc.date.accessioned2020-02-24T14:19:49Z
dc.date.available2020-02-24T14:19:49Z
dc.date.issued2020-02-07none
dc.identifier.other10.7554/eLife.49974
dc.identifier.urihttp://edoc.hu-berlin.de/18452/21941
dc.description.abstractAcross biological systems, cooperativity between proteins enables fast actions, supra-linear responses, and long-lasting molecular switches. In the nervous system, however, the function of cooperative interactions between voltage-dependent ionic channels remains largely unknown. Based on mathematical modeling, we here demonstrate that clusters of strongly cooperative ion channels can plausibly form bistable conductances. Consequently, clusters are permanently switched on by neuronal spiking, switched off by strong hyperpolarization, and remain in their state for seconds after stimulation. The resulting short-term memory of the membrane potential allows to generate persistent firing when clusters of cooperative channels are present together with non-cooperative spike-generating conductances. Dynamic clamp experiments in rodent cortical neurons confirm that channel cooperativity can robustly induce graded persistent activity – a single-cell based, multistable mnemonic firing mode experimentally observed in several brain regions. We therefore propose that ion channel cooperativity constitutes an efficient cell-intrinsic implementation for short-term memories at the voltage level.eng
dc.language.isoengnone
dc.publisherHumboldt-Universität zu Berlin
dc.rights(CC BY 4.0) Attribution 4.0 Internationalger
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/
dc.subject.ddc500 Naturwissenschaften und Mathematiknone
dc.titleClusters of cooperative ion channels enable a membrane-potential-based mechanism for short-term memorynone
dc.typearticle
dc.identifier.urnurn:nbn:de:kobv:11-110-18452/21941-9
dc.identifier.doihttp://dx.doi.org/10.18452/21201
dc.type.versionpublishedVersionnone
local.edoc.container-titleeLifenone
local.edoc.pages27none
local.edoc.anmerkungThis article was supported by the German Research Foundation (DFG) and the Open Access Publication Fund of Humboldt-Universität zu Berlin.none
local.edoc.type-nameZeitschriftenartikel
local.edoc.institutionLebenswissenschaftliche Fakultätnone
local.edoc.container-typeperiodical
local.edoc.container-type-nameZeitschrift
local.edoc.container-publisher-nameeLife Sciences Publicationsnone
local.edoc.container-publisher-placeCambridgenone
local.edoc.container-volume9none
dc.description.versionPeer Reviewednone
local.edoc.container-articlenumbere49974
dc.identifier.eissn2050-084X

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