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2020-04-08Zeitschriftenartikel DOI: 10.18452/21358
Healthspan Maintenance and Prevention of Parkinson’s-like Phenotypes with Hydroxytyrosol and Oleuropein Aglycone in C. elegans
dc.contributor.authorBrunetti, Giovanni
dc.contributor.authorDi Rosa, Gabriele
dc.contributor.authorScuto, Maria
dc.contributor.authorLeri, Manuela
dc.contributor.authorStefani, Massimo
dc.contributor.authorSchmitz-Linneweber, Christian
dc.contributor.authorCalabrese, Vittorio
dc.contributor.authorSaul, Nadine
dc.date.accessioned2020-04-14T13:51:24Z
dc.date.available2020-04-14T13:51:24Z
dc.date.issued2020-04-08none
dc.identifier.urihttp://edoc.hu-berlin.de/18452/22095
dc.description.abstractNumerous studies highlighted the beneficial effects of the Mediterranean diet (MD) in maintaining health, especially during ageing. Even neurodegeneration, which is part of the natural ageing process, as well as the foundation of ageing-related neurodegenerative disorders like Alzheimer’s and Parkinson’s disease (PD), was successfully targeted by MD. In this regard, olive oil and its polyphenolic constituents have received increasing attention in the last years. Thus, this study focuses on two main olive oil polyphenols, hydroxytyrosol (HT) and oleuropein aglycone (OLE), and their effects on ageing symptoms with special attention to PD. In order to avoid long-lasting, expensive, and ethically controversial experiments, the established invertebrate model organism Caenorhabditis elegans was used to test HT and OLE treatments. Interestingly, both polyphenols were able to increase the survival after heat stress, but only HT could prolong the lifespan in unstressed conditions. Furthermore, in aged worms, HT and OLE caused improvements of locomotive behavior and the attenuation of autofluorescence as a marker for ageing. In addition, by using three different C. elegans PD models, HT and OLE were shown i) to enhance locomotion in worms suffering from α-synuclein-expression in muscles or rotenone exposure, ii) to reduce α-synuclein accumulation in muscles cells, and iii) to prevent neurodegeneration in α-synuclein-containing dopaminergic neurons. Hormesis, antioxidative capacities and an activity-boost of the proteasome & phase II detoxifying enzymes are discussed as potential underlying causes for these beneficial effects. Further biological and medical trials are indicated to assess the full potential of HT and OLE and to uncover their mode of action.eng
dc.language.isoengnone
dc.publisherHumboldt-Universität zu Berlin
dc.rights(CC BY 4.0) Attribution 4.0 Internationalger
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/
dc.subjectC. eleganseng
dc.subjectpolyphenolseng
dc.subjectolive oileng
dc.subjecthealthspaneng
dc.subjectlifespaneng
dc.subjectageingeng
dc.subjectParkinson’s diseaseeng
dc.subject.ddc540 Chemie und zugeordnete Wissenschaftennone
dc.titleHealthspan Maintenance and Prevention of Parkinson’s-like Phenotypes with Hydroxytyrosol and Oleuropein Aglycone in C. elegansnone
dc.typearticle
dc.identifier.urnurn:nbn:de:kobv:11-110-18452/22095-5
dc.identifier.doihttp://dx.doi.org/10.18452/21358
dc.type.versionpublishedVersionnone
local.edoc.pages23none
local.edoc.type-nameZeitschriftenartikel
local.edoc.container-typeperiodical
local.edoc.container-type-nameZeitschrift
dc.description.versionPeer Reviewednone
dc.identifier.eissn1422-0067
dcterms.bibliographicCitation.doi10.3390/ijms21072588
dcterms.bibliographicCitation.journaltitleInternational journal of molecular sciencesnone
dcterms.bibliographicCitation.volume21none
dcterms.bibliographicCitation.issue7none
dcterms.bibliographicCitation.articlenumber2588
dcterms.bibliographicCitation.originalpublishernameMolecular Diversity Preservation Internationalnone
dcterms.bibliographicCitation.originalpublisherplaceBaselnone
bua.departmentLebenswissenschaftliche Fakultätnone
dcterms.bibliographicCitation.journalparttitleCentenarians—A Model to Study the Molecular Basis of Lifespan and Healthspan

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