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2000-09Zeitschriftenartikel DOI: 10.18452/21724
Mathematical modelling of the within-host dynamics of Plasmodium falciparum
dc.contributor.authorHoshen, M. B.
dc.contributor.authorHeinrich, Reinhart
dc.contributor.authorStein, W. D.
dc.contributor.authorGinsburg, H.
dc.date.accessioned2020-08-18T08:19:02Z
dc.date.available2020-08-18T08:19:02Z
dc.date.issued2000-09none
dc.identifier.other10.1017/S0031182099006368
dc.identifier.urihttp://edoc.hu-berlin.de/18452/22439
dc.description.abstractThe development of malaria due to Plasmodium falciparum is a complex, multi-stage process. It is usually characterized by an exponential growth in the number of parasite-infected erythrocytes, followed by marked oscillations in this number with a period of 48 h, which are eventually dampened. This course of events has been the subject of various mathematical models. In this paper we propose a new mathematical model for the in-host asexual erythrocytic development of P. falciparum malaria. Synchronicity of the infection is shown to be an inherent feature of infection, irrespective of the duration of merozoite release from the liver. It will, therefore, cause periodic symptoms, as known in malaria patients. We also simulate the effects of an induced host immune response and show how the level of immunity affects the development of disease. The simulations fit well with the clinical observations. We show how infection can become asynchronous and discuss the effect of desynchronization on the circulating and total parasitaemia and demonstrate that synchronized broods will show parasitaemia fluctuations.eng
dc.language.isoengnone
dc.publisherHumboldt-Universität zu Berlin
dc.rights.urihttp://rightsstatements.org/vocab/InC/1.0/
dc.subjectPlasmodium falciparumeng
dc.subjectmathematical modeleng
dc.subjectwithin-hosteng
dc.subjectsynchronyeng
dc.subject.ddc570 Biologienone
dc.subject.ddc572 Biochemienone
dc.subject.ddc510 Mathematiknone
dc.titleMathematical modelling of the within-host dynamics of Plasmodium falciparumnone
dc.typearticle
dc.identifier.urnurn:nbn:de:kobv:11-110-18452/22439-5
dc.identifier.doihttp://dx.doi.org/10.18452/21724
dc.type.versionpublishedVersionnone
local.edoc.container-titleParasitologynone
local.edoc.pages9none
local.edoc.anmerkungThis publication is with permission of the rights owner freely accessible due to an Alliance licence and a national licence (funded by the DFG, German Research Foundation) respectively.none
local.edoc.type-nameZeitschriftenartikel
local.edoc.institutionLebenswissenschaftliche Fakultätnone
local.edoc.container-typeperiodical
local.edoc.container-type-nameZeitschrift
local.edoc.container-publisher-nameCambridge University Pressnone
local.edoc.container-publisher-placeCambridge Univ. Pressnone
local.edoc.container-volume121none
local.edoc.container-issue3none
local.edoc.container-firstpage227none
local.edoc.container-lastpage235none
dc.description.versionPeer Reviewednone
dc.identifier.eissn1469-8161

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