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2020-06-28Zeitschriftenartikel DOI: 10.18452/22120
Toward Artificial Mussel-Glue Proteins: Differentiating Sequence Modules for Adhesion and Switchable Cohesion
dc.contributor.authorSandra, Arias López
dc.contributor.authorAmini, Shahrouz
dc.contributor.authorHorsch, Justus
dc.contributor.authorPretzler, Matthias
dc.contributor.authorRompel, Annette
dc.contributor.authorMelnyk, Inga
dc.contributor.authorSychev, Dmitrii
dc.contributor.authorFery, Andreas
dc.contributor.authorBörner, Hans G.
dc.date.accessioned2020-11-13T09:50:46Z
dc.date.available2020-11-13T09:50:46Z
dc.date.issued2020-06-28none
dc.identifier.urihttp://edoc.hu-berlin.de/18452/22787
dc.description.abstractArtificial mussel‐glue proteins with pH‐triggered cohesion control were synthesized by extending the tyrosinase activated polymerization of peptides to sequences with specific modules for cohesion control. The high propensity of these sequence sections to adopt β‐sheets is suppressed by switch defects. This allows enzymatic activation and polymerization to proceed undisturbed. The β‐sheet formation is regained after polymerization by changing the pH from 5.5 to 6.8, thereby triggering O→N acyl transfer rearrangements that activate the cohesion mechanism. The resulting artificial mussel glue proteins exhibit rapid adsorption on alumina surfaces. The coatings resist harsh hypersaline conditions, and reach remarkable adhesive energies of 2.64 mJ m−2 on silica at pH 6.8. In in situ switch experiments, the minor pH change increases the adhesive properties of a coating by 300 % and nanoindentation confirms the cohesion mechanism to improve bulk stiffness by around 200 %.eng
dc.language.isoengnone
dc.publisherHumboldt-Universität zu Berlin
dc.rights(CC BY 4.0) Attribution 4.0 Internationalger
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/
dc.subjectadhesioneng
dc.subjectcohesion controleng
dc.subjectenzyme-induced polymerizationeng
dc.subjectmussel glueeng
dc.subjectsythetic proteineng
dc.subject.ddc540 Chemie und zugeordnete Wissenschaftennone
dc.titleToward Artificial Mussel-Glue Proteins: Differentiating Sequence Modules for Adhesion and Switchable Cohesionnone
dc.typearticle
dc.identifier.urnurn:nbn:de:kobv:11-110-18452/22787-8
dc.identifier.doihttp://dx.doi.org/10.18452/22120
dc.type.versionpublishedVersionnone
local.edoc.pages5none
local.edoc.type-nameZeitschriftenartikel
local.edoc.container-typeperiodical
local.edoc.container-type-nameZeitschrift
dc.description.versionPeer Reviewednone
dc.identifier.eissn1521-3773
dcterms.bibliographicCitation.doi10.1002/anie.202008515
dcterms.bibliographicCitation.journaltitleAngewandte Chemienone
dcterms.bibliographicCitation.volume59none
dcterms.bibliographicCitation.issue42none
dcterms.bibliographicCitation.originalpublishernameWiley-VCHnone
dcterms.bibliographicCitation.originalpublisherplaceWeinheimnone
dcterms.bibliographicCitation.pagestart18495none
dcterms.bibliographicCitation.pageend18499none
bua.departmentMathematisch-Naturwissenschaftliche Fakultätnone

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