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2020-09-24Zeitschriftenartikel DOI: 10.18452/22315
Instantaneous Cardiac Baroreflex Sensitivity: xBRS Method Quantifies Heart Rate Blood Pressure Variability Ratio at Rest and During Slow Breathing
dc.contributor.authorWessel, Niels
dc.contributor.authorGapelyuk, Andrej
dc.contributor.authorWeiß, Jonas
dc.contributor.authorSchmidt, Martin
dc.contributor.authorKraemer, Jan F
dc.contributor.authorBerg, Karsten
dc.contributor.authorMalberg, Hagen
dc.contributor.authorStepan, Holger
dc.contributor.authorKurths, Jürgen
dc.date.accessioned2021-01-08T08:46:14Z
dc.date.available2021-01-08T08:46:14Z
dc.date.issued2020-09-24none
dc.identifier.other10.3389/fnins.2020.547433
dc.identifier.urihttp://edoc.hu-berlin.de/18452/22946
dc.description.abstractSpontaneous baroreflex sensitivity (BRS) is a widely used tool for the quantification of the cardiovascular regulation. Numerous groups use the xBRS method, which calculates the cross-correlation between the systolic beat-to-beat blood pressure and the R-R interval (resampled at 1 Hz) in a 10 s sliding window, with 0–5 s delays for the interval. The delay with the highest correlation is selected and, if significant, the quotient of the standard deviations of the R-R intervals and the systolic blood pressures is recorded as the corresponding xBRS value. In this paper we test the hypothesis that the xBRS method quantifies the causal interactions of spontaneous BRS from non-invasive measurements at rest. We use the term spontaneous BRS in the sense of the sensitivity curve is calculated from non-interventional, i.e., spontaneous, baroreceptor activity. This study includes retrospective analysis of 1828 measurements containing ECG as well as continues blood pressure under resting conditions. Our results show a high correlation between the heart rate – systolic blood pressure variability (HRV/BPV) quotient and the xBRS (r = 0.94, p < 0.001). For a deeper understanding we conducted two surrogate analyses by substituting the systolic blood pressure by its reversed time series. These showed that the xBRS method was not able to quantify causal relationships between the two signals. It was not possible to distinguish between random and baroreflex controlled sequences. It appears xBRS rather determines the HRV/BPV quotient. We conclude that the xBRS method has a potentially large bias in characterizing the capacity of the arterial baroreflex under resting conditions. During slow breathing, estimates for xBRS are significantly increased, which clearly shows that measurements at rest only involve limited baroreflex activity, but does neither challenge, nor show the full range of the arterial baroreflex regulatory capacity. We show that xBRS is exclusively dominated by the heart rate to systolic blood pressure ratio (r = 0.965, p < 0.001). Further investigations should focus on additional autonomous testing procedures such as slow breathing or orthostatic testing to provide a basis for a non-invasive evaluation of baroreflex sensitivity.eng
dc.language.isoengnone
dc.publisherHumboldt-Universität zu Berlin
dc.rights(CC BY 4.0) Attribution 4.0 Internationalger
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/
dc.subjectbarorecepter reflex sensitivityeng
dc.subjectheart rate variabilityeng
dc.subjectblood pressure variabilityeng
dc.subjectslow breathingeng
dc.subjectresteng
dc.subject.ddc610 Medizin und Gesundheitnone
dc.titleInstantaneous Cardiac Baroreflex Sensitivity: xBRS Method Quantifies Heart Rate Blood Pressure Variability Ratio at Rest and During Slow Breathingnone
dc.typearticle
dc.identifier.urnurn:nbn:de:kobv:11-110-18452/22946-4
dc.identifier.doihttp://dx.doi.org/10.18452/22315
dc.type.versionpublishedVersionnone
local.edoc.container-titleFrontiers in neurosciencenone
local.edoc.pages9none
local.edoc.anmerkungThis article was supported by the German Research Foundation (DFG) and the Open Access Publication Fund of Humboldt-Universität zu Berlin.none
local.edoc.type-nameZeitschriftenartikel
local.edoc.institutionMathematisch-Naturwissenschaftliche Fakultätnone
local.edoc.container-typeperiodical
local.edoc.container-type-nameZeitschrift
local.edoc.container-publisher-nameFrontiers Research Foundationnone
local.edoc.container-publisher-placeLausannenone
local.edoc.container-volume14none
dc.description.versionPeer Reviewednone
local.edoc.container-articlenumber547433none
dc.identifier.eissn1662-453X

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