Show simple item record

2020-07-30Zeitschriftenartikel DOI: 10.18452/22486
The modulating impact of cigarette smoking on brain structure in panic disorder: a voxel-based morphometry study
dc.contributor.authorKunas, Stefanie
dc.contributor.authorHilbert, Kevin
dc.contributor.authorYang, Yunbo
dc.contributor.authorRichter, Jan
dc.contributor.authorHamm, Alfons
dc.contributor.authorWittmann, André
dc.contributor.authorPfleiderer, Bettina
dc.contributor.authorHerrmann, Martin J.
dc.contributor.authorLang, Thomas
dc.contributor.authorLotze, Martin
dc.contributor.authorDeckert, Jürgen
dc.contributor.authorArolt, Volker
dc.contributor.authorWittchen, Hans-Ulrich
dc.contributor.authorStraube, Benjamin
dc.contributor.authorKircher, Tilo
dc.contributor.authorGerlach, Alexander L.
dc.contributor.authorLueken, Ulrike
dc.date.accessioned2021-02-16T13:52:15Z
dc.date.available2021-02-16T13:52:15Z
dc.date.issued2020-07-30none
dc.identifier.other10.1093/scan/nsaa103
dc.identifier.urihttp://edoc.hu-berlin.de/18452/23100
dc.description.abstractCigarette smoking increases the likelihood of developing anxiety disorders, among them panic disorder (PD). While brain structures altered by smoking partly overlap with morphological changes identified in PD, the modulating impact of smoking as a potential confounder on structural alterations in PD has not yet been addressed. In total, 143 PD patients (71 smokers) and 178 healthy controls (62 smokers) participated in a multicenter magnetic resonance imaging (MRI) study. T1-weighted images were used to examine brain structural alterations using voxel-based morphometry in a priori defined regions of the defensive system network. PD was associated with gray matter volume reductions in the amygdala and hippocampus. This difference was driven by non-smokers and absent in smoking subjects. Bilateral amygdala volumes were reduced with increasing health burden (neither PD nor smoking > either PD or smoking > both PD and smoking). As smoking can narrow or diminish commonly observed structural abnormalities in PD, the effect of smoking should be considered in MRI studies focusing on patients with pathological forms of fear and anxiety. Future studies are needed to determine if smoking may increase the risk for subsequent psychopathology via brain functional or structural alterations.eng
dc.language.isoengnone
dc.publisherHumboldt-Universität zu Berlin
dc.rights(CC BY 4.0) Attribution 4.0 Internationalger
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/
dc.subjectsmokingeng
dc.subjectgray matter volumeeng
dc.subjectpanic disordereng
dc.subjectamygdalaeng
dc.subjecthippocampuseng
dc.subject.ddc610 Medizin und Gesundheitnone
dc.titleThe modulating impact of cigarette smoking on brain structure in panic disorder: a voxel-based morphometry studynone
dc.typearticle
dc.identifier.urnurn:nbn:de:kobv:11-110-18452/23100-2
dc.identifier.doihttp://dx.doi.org/10.18452/22486
dc.type.versionpublishedVersionnone
local.edoc.container-titleSocial cognitive and affective neurosciencenone
local.edoc.pages11none
local.edoc.anmerkungThis article was supported by the German Research Foundation (DFG) and the Open Access Publication Fund of Humboldt-Universität zu Berlin.none
local.edoc.type-nameZeitschriftenartikel
local.edoc.institutionLebenswissenschaftliche Fakultätnone
local.edoc.container-typeperiodical
local.edoc.container-type-nameZeitschrift
local.edoc.container-publisher-nameOxford Univ. Pressnone
local.edoc.container-publisher-placeOxfordnone
local.edoc.container-volume15none
local.edoc.container-issue8none
local.edoc.container-firstpage849none
local.edoc.container-lastpage859none
dc.description.versionPeer Reviewednone
dc.identifier.eissn1749-5024

Show simple item record