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2020-12-08Zeitschriftenartikel DOI: 10.3389/fphys.2020.596844
Cardiac Autonomic Dysfunction and Incidence of de novo Atrial Fibrillation: Heart Rate Variability vs. Heart Rate Complexity
dc.contributor.authorWessel, Niels
dc.contributor.authorBerg, Karsten
dc.contributor.authorKraemer, Jan
dc.contributor.authorGapelyuk, Andrej
dc.contributor.authorRietsch, Katrin
dc.contributor.authorHauser, Tino
dc.contributor.authorKurths, Jürgen
dc.contributor.authorWenzel, Dave
dc.contributor.authorKlein, Norbert
dc.contributor.authorKolb, Christof
dc.contributor.authorBelke, Roberto
dc.contributor.authorSchirdewan, Alexander
dc.contributor.authorKääb, Stefan
dc.date.accessioned2021-04-09T08:17:22Z
dc.date.available2021-04-09T08:17:22Z
dc.date.issued2020-12-08none
dc.date.updated2020-12-22T05:08:08Z
dc.identifier.urihttp://edoc.hu-berlin.de/18452/23305
dc.description.abstractBackgroundThe REACT DX registry evaluates standard therapies to episodes of long-lasting atrial tachyarrhythmias and assesses the quality of sensing and stability of the lead and the implantable cardioverter-defibrillator (ICD) (BIOTRONIK Lumax VR-T DX and successors) over at least a 1-year follow-up period. ObjectiveTo study the association between the risk of de novo device-detected atrial fibrillation (AF), the autonomic perturbations before the onset of paroxysmal AF and a 7-days heart rate variability (7dHRV) 1 month after ICD implantation. MethodsThe registry consists of 234 patients implanted with an ICD, including 10 with de novo long-lasting atrial tachyarrhythmias with no prior history of AF. The patients were matched via the propensity-score methodology as well as for properties directly influencing the ECGs recorded using GE CardioMem CM 3000. Heart rate variability (HRV) analysis was performed using standard parameters from time- and frequency-domains, and from non-linear dynamics. ResultsNo linear HRV was associated with an increased risk of AF (p = n.s.). The only significant approach was derived from symbolic dynamics with the parameter “forbidden words” which distinguished both groups on all 7 days of measurements (p < 0.05), thereby quantifying the heart rate complexity (HRC) as drastically lower in the de novo AF group. ConclusionCardiac autonomic dysfunction denoted by low HRC may be associated with higher AF incidence. For patients with mild to moderate heart failure, standard HRV parameters are not appropriate to quantify cardiac autonomic perturbations before the onset of AF. Further studies are needed to determine the individual risk for AF that would enable interventions to restore autonomic balance in the general population.eng
dc.language.isoengnone
dc.publisherHumboldt-Universität zu Berlin
dc.rights(CC BY 4.0) Attribution 4.0 Internationalger
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/
dc.subjectheart rate variabilityeng
dc.subjectheart rate complexityeng
dc.subjectcardiac autonomic dysfunctioneng
dc.subjectatrial fibrillationeng
dc.subjectimplantable cardioverter defibrillatoreng
dc.subject.ddc610 Medizin und Gesundheitnone
dc.titleCardiac Autonomic Dysfunction and Incidence of de novo Atrial Fibrillation: Heart Rate Variability vs. Heart Rate Complexitynone
dc.typearticle
dc.identifier.urnurn:nbn:de:kobv:11-110-18452/23305-2
dc.identifier.doi10.3389/fphys.2020.596844none
dc.identifier.doihttp://dx.doi.org/10.18452/22697
dc.type.versionpublishedVersionnone
local.edoc.container-titleFrontiers in physiologynone
local.edoc.pages11none
local.edoc.anmerkungThis article was supported by the German Research Foundation (DFG) and the Open Access Publication Fund of Humboldt-Universität zu Berlin.none
local.edoc.type-nameZeitschriftenartikel
local.edoc.institutionMathematisch-Naturwissenschaftliche Fakultätnone
local.edoc.container-typeperiodical
local.edoc.container-type-nameZeitschrift
local.edoc.container-publisher-nameFrontiers Research Foundationnone
local.edoc.container-publisher-placeLausannenone
local.edoc.container-volume11none
dc.description.versionPeer Reviewednone
local.edoc.container-articlenumber596844none
dc.identifier.eissn1664-042X
local.edoc.affiliationWessel, Niels; 1Department of Physics, Humboldt-Universität zu Berlin, Berlin, Germanynone
local.edoc.affiliationBerg, Karsten; 1Department of Physics, Humboldt-Universität zu Berlin, Berlin, Germanynone
local.edoc.affiliationKraemer, Jan F.; 1Department of Physics, Humboldt-Universität zu Berlin, Berlin, Germanynone
local.edoc.affiliationGapelyuk, Andrej; 1Department of Physics, Humboldt-Universität zu Berlin, Berlin, Germanynone
local.edoc.affiliationRietsch, Katrin; 2BIOTRONIK, Berlin, Germanynone
local.edoc.affiliationHauser, Tino; 2BIOTRONIK, Berlin, Germanynone
local.edoc.affiliationKurths, Jürgen; 1Department of Physics, Humboldt-Universität zu Berlin, Berlin, Germanynone
local.edoc.affiliationWenzel, Dave; 5Clinic for Cardiology and Angiology, University Hospital Magdeburg, Magdeburg, Germanynone
local.edoc.affiliationKlein, Norbert; 6St. Georg Hospital, Leipzig, Germanynone
local.edoc.affiliationKolb, Christof; 7Deutsches Herzzentrum München, Klinik für Herz- und Kreislauferkrankungen, Abteilung für Elektrophysiologie, Faculty of Medicine, Technische Universität München, Munich, Germanynone
local.edoc.affiliationBelke, Roberto; 2BIOTRONIK, Berlin, Germanynone
local.edoc.affiliationSchirdewan, Alexander; 8Sana Klinikum Lichtenberg, Berlin, Germanynone
local.edoc.affiliationKääb, Stefan; 9Medical Center of Ludwig-Maximilians-University of Munich, Munich, Germanynone

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