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2021-01-27Zeitschriftenartikel DOI: 10.3389/fnhum.2020.593365
Muscle Synergies in Patients With Multiple Sclerosis Reveal Demand-Specific Alterations in the Modular Organization of Locomotion
dc.contributor.authorJanshen, Lars
dc.contributor.authorSantuz, Alessandro
dc.contributor.authorArampatzis, Adamantios
dc.date.accessioned2021-04-09T08:45:58Z
dc.date.available2021-04-09T08:45:58Z
dc.date.issued2021-01-27none
dc.date.updated2021-02-10T05:36:17Z
dc.identifier.urihttp://edoc.hu-berlin.de/18452/23306
dc.description.abstractFor patients with multiple sclerosis (MS), deficits in gait significantly reduce the quality of life. Using the concept of muscle synergies, this study investigated the modular organization of motor control during level and inclined walking in MS patients (MSP) compared with healthy participants (HP) to identify the potential demand-specific adjustments in motor control in MSP. We hypothesized a widening of the time-dependent activation patterns (motor primitives) in MSP to increase the overlap of temporally-adjacent muscle synergies, especially during inclined walking, as a strategy to increase the robustness of motor control, thus compensating pathology-related deficits. We analyzed temporal gait parameters and muscle synergies from myoelectric signals of 13 ipsilateral leg muscles using non-negative matrix factorization. Compared with HP, MSP demonstrated a widening in the time-dependent coefficients (motor primitives), as well as altered relative muscle contribution (motor modules), in certain synergies during level and inclined walking. Moreover, inclined walking revealed a demand-specific adjustment in the modular organization in MSP, resulting in an extra synergy compared with HP. This further increased the overlap of temporally-adjacent muscle synergies to provide sufficient robustness in motor control to accomplish the more demanding motor task while coping with pathology-related motor deficits during walking.eng
dc.language.isoengnone
dc.publisherHumboldt-Universität zu Berlin
dc.rights(CC BY 4.0) Attribution 4.0 Internationalger
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/
dc.subjectmuscle synergieseng
dc.subjectmultiple sclerosiseng
dc.subjectlocomotioneng
dc.subjectmotor controleng
dc.subjectinclined walkingeng
dc.subjectdemand-specificeng
dc.subject.ddc610 Medizin und Gesundheitnone
dc.titleMuscle Synergies in Patients With Multiple Sclerosis Reveal Demand-Specific Alterations in the Modular Organization of Locomotionnone
dc.typearticle
dc.identifier.urnurn:nbn:de:kobv:11-110-18452/23306-8
dc.identifier.doi10.3389/fnhum.2020.593365none
dc.identifier.doihttp://dx.doi.org/10.18452/22698
dc.type.versionpublishedVersionnone
local.edoc.container-titleFrontiers in human neurosciencenone
local.edoc.pages13none
local.edoc.anmerkungThis article was supported by the German Research Foundation (DFG) and the Open Access Publication Fund of Humboldt-Universität zu Berlin.none
local.edoc.type-nameZeitschriftenartikel
local.edoc.institutionKultur-, Sozial- und Bildungswissenschaftliche Fakultätnone
local.edoc.container-typeperiodical
local.edoc.container-type-nameZeitschrift
local.edoc.container-publisher-nameFrontiers Research Foundationnone
local.edoc.container-publisher-placeLausannenone
local.edoc.container-volume14none
dc.description.versionPeer Reviewednone
local.edoc.container-articlenumber593365none
dc.identifier.eissn1662-5161
local.edoc.affiliationJanshen, Lars; 1Department of Training and Movement Sciences, Humboldt-Universität zu Berlin, Berlin, Germanynone
local.edoc.affiliationSantuz, Alessandro; 1Department of Training and Movement Sciences, Humboldt-Universität zu Berlin, Berlin, Germanynone
local.edoc.affiliationArampatzis, Adamantios; 1Department of Training and Movement Sciences, Humboldt-Universität zu Berlin, Berlin, Germanynone

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