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2021-08-25Zeitschriftenartikel DOI: 10.18452/23549
GABAB Receptor-Mediated Regulation of Dendro-Somatic Synergy in Layer 5 Pyramidal Neurons
dc.contributor.authorSchulz, Jan M.
dc.contributor.authorKay, Jim W.
dc.contributor.authorBischofberger, Josef
dc.contributor.authorLarkum, Matthew
dc.date.accessioned2021-10-14T11:45:36Z
dc.date.available2021-10-14T11:45:36Z
dc.date.issued2021-08-25none
dc.date.updated2021-09-15T03:04:30Z
dc.identifier.urihttp://edoc.hu-berlin.de/18452/24207
dc.description.abstractSynergistic interactions between independent synaptic input streams may fundamentally change the action potential (AP) output. Using partial information decomposition, we demonstrate here a substantial contribution of synergy between somatic and apical dendritic inputs to the information in the AP output of L5b pyramidal neurons. Activation of dendritic GABAB receptors (GABABRs), known to decrease APs in vivo, potently decreased synergy and increased somatic control of AP output. Synergy was the result of the voltage-dependence of the transfer resistance between dendrite and soma, which showed a two-fold increase per 28.7 mV dendritic depolarization. GIRK channels activated by dendritic GABABRs decreased voltage-dependent transfer resistances and AP output. In contrast, inhibition of dendritic L-type Ca2+ channels prevented high-frequency bursts of APs, but did not affect dendro-somatic synergy. Finally, we show that NDNF-positive neurogliaform cells effectively control somatic AP via synaptic activation of dendritic GIRK channels. These results uncover a novel inhibitory mechanism that powerfully gates cellular information flow in the cortex.eng
dc.language.isoengnone
dc.publisherHumboldt-Universität zu Berlin
dc.rights(CC BY 4.0) Attribution 4.0 Internationalger
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/
dc.subjectneocortexeng
dc.subjectdendriteeng
dc.subjectinterneuroneng
dc.subjectneurogliaform cellseng
dc.subjectGIRK channelseng
dc.subjectinterhemispheric inhibitioneng
dc.subjectL-type calcium channelseng
dc.subjectHCN channels – h currenteng
dc.subject.ddc610 Medizin und Gesundheitnone
dc.titleGABAB Receptor-Mediated Regulation of Dendro-Somatic Synergy in Layer 5 Pyramidal Neuronsnone
dc.typearticle
dc.identifier.urnurn:nbn:de:kobv:11-110-18452/24207-4
dc.identifier.doihttp://dx.doi.org/10.18452/23549
dc.type.versionpublishedVersionnone
local.edoc.pages19none
local.edoc.type-nameZeitschriftenartikel
local.edoc.container-typeperiodical
local.edoc.container-type-nameZeitschrift
dc.description.versionPeer Reviewednone
dc.identifier.eissn1662-5102
dcterms.bibliographicCitation.doi10.3389/fncel.2021.718413none
dcterms.bibliographicCitation.journaltitleFrontiers in cellular neurosciencenone
dcterms.bibliographicCitation.volume15none
dcterms.bibliographicCitation.articlenumber718413none
dcterms.bibliographicCitation.originalpublishernameFrontiers Research Foundationnone
dcterms.bibliographicCitation.originalpublisherplaceLausannenone
bua.import.affiliationSchulz, Jan M.; 1Department of Biomedicine, University of Basel, Basel, Switzerlandnone
bua.import.affiliationKay, Jim W.; 2Department of Statistics, University of Glasgow, Glasgow, United Kingdomnone
bua.import.affiliationBischofberger, Josef; 1Department of Biomedicine, University of Basel, Basel, Switzerlandnone
bua.import.affiliationLarkum, Matthew E.; 3Institute for Biology, Humboldt-Universität zu Berlin, Berlin, Germanynone
bua.departmentLebenswissenschaftliche Fakultätnone

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