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2021-07-05Zeitschriftenartikel DOI: 10.18452/23580
Neural processing of emotional facial stimuli in specific phobia: An fMRI study
dc.contributor.authorBöhnlein, Joscha
dc.contributor.authorLeehr, Elisabeth
dc.contributor.authorRoesmann, Kati
dc.contributor.authorSappelt, Teresa
dc.contributor.authorPlatte, Ole
dc.contributor.authorGrotegerd, Dominik
dc.contributor.authorSindermann, Lisa
dc.contributor.authorRepple, Jonathan
dc.contributor.authorOpel, Nils
dc.contributor.authorMeinert, Susanne
dc.contributor.authorLemke, Hannah
dc.contributor.authorBorgers, Tiana
dc.contributor.authorDohm, Katharina
dc.contributor.authorEnneking, Verena
dc.contributor.authorGoltermann, Janik
dc.contributor.authorWaltemate, Lena
dc.contributor.authorHülsmann, Carina
dc.contributor.authorThiel, Katharina
dc.contributor.authorWinter, Nils
dc.contributor.authorBauer, Jochen
dc.contributor.authorLueken, Ulrike
dc.contributor.authorStraube, Thomas
dc.contributor.authorJunghöfer, Markus
dc.contributor.authorDannlowski, Udo
dc.date.accessioned2021-10-19T09:44:52Z
dc.date.available2021-10-19T09:44:52Z
dc.date.issued2021-07-05none
dc.date.updated2021-09-08T00:49:43Z
dc.identifier.urihttp://edoc.hu-berlin.de/18452/24234
dc.description.abstractBackground Patients with specific phobia (SP) show altered brain activation when confronted with phobia-specific stimuli. It is unclear whether this pathogenic activation pattern generalizes to other emotional stimuli. This study addresses this question by employing a well-powered sample while implementing an established paradigm using nonspecific aversive facial stimuli. Methods N = 111 patients with SP, spider subtype, and N = 111 healthy controls (HCs) performed a supraliminal emotional face-matching paradigm contrasting aversive faces versus shapes in a 3-T magnetic resonance imaging scanner. We performed region of interest (ROI) analyses for the amygdala, the insula, and the anterior cingulate cortex using univariate as well as machine-learning-based multivariate statistics based on this data. Additionally, we investigated functional connectivity by means of psychophysiological interaction (PPI). Results Although the presentation of emotional faces showed significant activation in all three ROIs across both groups, no group differences emerged in all ROIs. Across both groups and in the HC > SP contrast, PPI analyses showed significant task-related connectivity of brain areas typically linked to higher-order emotion processing with the amygdala. The machine learning approach based on whole-brain activity patterns could significantly differentiate the groups with 73% balanced accuracy. Conclusions Patients suffering from SP are characterized by differences in the connectivity of the amygdala and areas typically linked to emotional processing in response to aversive facial stimuli (inferior parietal cortex, fusiform gyrus, middle cingulate, postcentral cortex, and insula). This might implicate a subtle difference in the processing of nonspecific emotional stimuli and warrants more research furthering our understanding of neurofunctional alteration in patients with SP.eng
dc.description.sponsorshipDeutsche Forschungsgemeinschaft http://dx.doi.org/10.13039/501100001659
dc.language.isoengnone
dc.publisherHumboldt-Universität zu Berlin
dc.rights(CC BY 4.0) Attribution 4.0 Internationalger
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/
dc.subjectbrain imaging/neuroimagingeng
dc.subjectfunctional MRIeng
dc.subjectneuroimagingeng
dc.subjectphobia/phobic disorderseng
dc.subject.ddc610 Medizin und Gesundheitnone
dc.titleNeural processing of emotional facial stimuli in specific phobia: An fMRI studynone
dc.typearticle
dc.identifier.urnurn:nbn:de:kobv:11-110-18452/24234-4
dc.identifier.doihttp://dx.doi.org/10.18452/23580
dc.type.versionpublishedVersionnone
local.edoc.pages14none
local.edoc.type-nameZeitschriftenartikel
local.edoc.container-typeperiodical
local.edoc.container-type-nameZeitschrift
dc.description.versionPeer Reviewednone
dc.identifier.eissn1520-6394
dcterms.bibliographicCitation.doi10.1002/da.23191none
dcterms.bibliographicCitation.journaltitleDepression and anxietynone
dcterms.bibliographicCitation.volume38none
dcterms.bibliographicCitation.issue8none
dcterms.bibliographicCitation.originalpublishernameWiley Intersciencenone
dcterms.bibliographicCitation.originalpublisherplaceNew York, NY [u.a.]none
dcterms.bibliographicCitation.pagestart846none
dcterms.bibliographicCitation.pageend859none
bua.import.affiliationBöhnlein, Joscha; 1Institute for Translational Psychiatry University of Münster Münster Germanynone
bua.import.affiliationLeehr, Elisabeth J.; 1Institute for Translational Psychiatry University of Münster Münster Germanynone
bua.import.affiliationRoesmann, Kati; 2Institute for Clinical Psychology University of Siegen Siegen Germanynone
bua.import.affiliationSappelt, Teresa; 1Institute for Translational Psychiatry University of Münster Münster Germanynone
bua.import.affiliationPlatte, Ole; 1Institute for Translational Psychiatry University of Münster Münster Germanynone
bua.import.affiliationGrotegerd, Dominik; 1Institute for Translational Psychiatry University of Münster Münster Germanynone
bua.import.affiliationSindermann, Lisa; 1Institute for Translational Psychiatry University of Münster Münster Germanynone
bua.import.affiliationRepple, Jonathan; 1Institute for Translational Psychiatry University of Münster Münster Germanynone
bua.import.affiliationOpel, Nils; 1Institute for Translational Psychiatry University of Münster Münster Germanynone
bua.import.affiliationMeinert, Susanne; 1Institute for Translational Psychiatry University of Münster Münster Germanynone
bua.import.affiliationLemke, Hannah; 1Institute for Translational Psychiatry University of Münster Münster Germanynone
bua.import.affiliationBorgers, Tiana; 1Institute for Translational Psychiatry University of Münster Münster Germanynone
bua.import.affiliationDohm, Katharina; 1Institute for Translational Psychiatry University of Münster Münster Germanynone
bua.import.affiliationEnneking, Verena; 1Institute for Translational Psychiatry University of Münster Münster Germanynone
bua.import.affiliationGoltermann, Janik; 1Institute for Translational Psychiatry University of Münster Münster Germanynone
bua.import.affiliationWaltemate, Lena; 1Institute for Translational Psychiatry University of Münster Münster Germanynone
bua.import.affiliationHülsmann, Carina; 1Institute for Translational Psychiatry University of Münster Münster Germanynone
bua.import.affiliationThiel, Katharina; 1Institute for Translational Psychiatry University of Münster Münster Germanynone
bua.import.affiliationWinter, Nils; 1Institute for Translational Psychiatry University of Münster Münster Germanynone
bua.import.affiliationBauer, Jochen; 4Clinic for Radiology, School of Medicine University of Münster Münster Germanynone
bua.import.affiliationLueken, Ulrike; 5 Department of Psychology Humboldt‐Universität zu Berlin Berlin Germanynone
bua.import.affiliationStraube, Thomas; 6Institute of Medical Psychology and Systems Neuroscience University of Münster Münster Germanynone
bua.import.affiliationJunghöfer, Markus; 3Institute for Biomagnetism and Biosignalanalysis University of Münster Münster Germanynone
bua.departmentLebenswissenschaftliche Fakultätnone

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