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2021-04-24Zeitschriftenartikel DOI: 10.3390/md19050241
Cyanobacteria—From the Oceans to the Potential Biotechnological and Biomedical Applications
dc.contributor.authorKhalifa, Shaden A. M.
dc.contributor.authorShedid, Eslam S.
dc.contributor.authorSaied, Essa M.
dc.contributor.authorJassbi, Amir Reza
dc.contributor.authorJamebozorgi, Fatemeh H.
dc.contributor.authorRateb, Mostafa E.
dc.contributor.authorDu, Ming
dc.contributor.authorAbdel-Daim, Mohamed M.
dc.contributor.authorKai, Guo-Yin
dc.contributor.authorAl-Hammady, Montaser A. M.
dc.contributor.authorXiao, Jianbo
dc.contributor.authorGuo, Zhiming
dc.contributor.authorEl-Seedi, Hesham R.
dc.date.accessioned2021-10-27T07:29:38Z
dc.date.available2021-10-27T07:29:38Z
dc.date.issued2021-04-24none
dc.date.updated2021-05-03T18:10:37Z
dc.identifier.urihttp://edoc.hu-berlin.de/18452/24267
dc.description.abstractCyanobacteria are photosynthetic prokaryotic organisms which represent a significantsource of novel, bioactive, secondary metabolites, and they are also considered an abundant source ofbioactive compounds/drugs, such as dolastatin, cryptophycin 1, curacin toyocamycin, phytoalexin,cyanovirin-N and phycocyanin. Some of these compounds have displayed promising results insuccessful Phase I, II, III and IV clinical trials. Additionally, the cyanobacterial compounds applied tomedical research have demonstrated an exciting future with great potential to be developed into newmedicines. Most of these compounds have exhibited strong pharmacological activities, includingneurotoxicity, cytotoxicity and antiviral activity against HCMV, HSV-1, HHV-6 and HIV-1, so thesemetabolites could be promising candidates for COVID-19 treatment. Therefore, the effective large-scale production of natural marine products through synthesis is important for resolving the existingissues associated with chemical isolation, including small yields, and may be necessary to betterinvestigate their biological activities. Herein, we highlight the total synthesized and stereochemicaldeterminations of the cyanobacterial bioactive compounds. Furthermore, this review primarilyfocuses on the biotechnological applications of cyanobacteria, including applications as cosmetics,food supplements, and the nanobiotechnological applications of cyanobacterial bioactive compoundsin potential medicinal applications for various human diseases are discussed.eng
dc.description.sponsorshipStockholm University
dc.language.isoengnone
dc.publisherHumboldt-Universität zu Berlin
dc.rights(CC BY 4.0) Attribution 4.0 Internationalger
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/
dc.subjectcyanobacteriaeng
dc.subjectclinical trialseng
dc.subjectantioxidanteng
dc.subjectantiviraleng
dc.subjectCOVID-19eng
dc.subjectdietary supplementseng
dc.subjectbiotechnological applicationseng
dc.subjecttotal synthesiseng
dc.subject.ddc540 Chemie und zugeordnete Wissenschaftennone
dc.subject.ddc610 Medizin und Gesundheitnone
dc.titleCyanobacteria—From the Oceans to the Potential Biotechnological and Biomedical Applicationsnone
dc.typearticle
dc.identifier.urnurn:nbn:de:kobv:11-110-18452/24267-9
dc.identifier.doi10.3390/md19050241none
dc.identifier.doihttp://dx.doi.org/10.18452/23609
dc.type.versionpublishedVersionnone
local.edoc.container-titleMarine Drugsnone
local.edoc.pages35none
local.edoc.type-nameZeitschriftenartikel
local.edoc.institutionMathematisch-Naturwissenschaftliche Fakultätnone
local.edoc.container-typeperiodical
local.edoc.container-type-nameZeitschrift
local.edoc.container-publisher-nameMDPInone
local.edoc.container-publisher-placeBaselnone
local.edoc.container-volume19none
local.edoc.container-issue5none
dc.description.versionPeer Reviewednone
local.edoc.container-articlenumber241none
dc.identifier.eissn1660-3397
local.edoc.affiliationKhalifa, Shaden A. M.; Department of Molecular Biosciences, Wenner-Gren Institute, Stockholm University, SE-106 91 Stockholm, Sweden, shaden.khalifa@su.senone
local.edoc.affiliationShedid, Eslam S.; Department of Chemistry, Faculty of Science, Menoufia University, Shebin El-Kom 32512, Egypt, eslamshaker566@yahoo.comnone
local.edoc.affiliationSaied, Essa M.; Chemistry Department, Faculty of Science, Suez Canal University, Ismailia 41522, Egypt, saiedess@hu-berlin.de; Institut für Chemie, Humboldt-Universität zu Berlin, Brook-Taylor-Straße 2, 12489 Berlin, Germany, saiedess@hu-berlin.denone
local.edoc.affiliationJassbi, Amir Reza; Medicinal and Natural Products Chemistry Research Center, Shiraz University of Medical Sciences, Shiraz 71348-53734, Iran, jassbiar@sums.ac.irnone
local.edoc.affiliationJamebozorgi, Fatemeh H.; Medicinal and Natural Products Chemistry Research Center, Shiraz University of Medical Sciences, Shiraz 71348-53734, Iran, fh_esfand@yahoo.comnone
local.edoc.affiliationRateb, Mostafa E.; School of Computing, Engineering & Physical Sciences, University of the West of Scotland, High Street, Paisley PA1 2BE, UK, mostafa.rateb@uws.ac.uknone
local.edoc.affiliationDu, Ming; School of Food Science and Technology, National Engineering Research Center of Seafood, Dalian Polytechnic University, Dalian 116034, China, duming@dlpu.edu.cnnone
local.edoc.affiliationAbdel-Daim, Mohamed M.; Pharmacology Department, Faculty of Veterinary Medicine, Suez Canal University, Ismailia 41522, Egypt, abdeldaim.m@vet.suez.edu.egnone
local.edoc.affiliationKai, Guo-Yin; Laboratory of Medicinal Plant Biotechnology, College of Pharmacy, Zhejiang Chinese Medical University, Hangzhou 311402, China, kaiguoyin@zcmu.edu.cnnone
local.edoc.affiliationAl-Hammady, Montaser A. M.; National Institute of Oceanography & Fisheries, NIOF, Cairo 11516, Egypt, Coralreef_niof1@yahoo.comnone
local.edoc.affiliationXiao, Jianbo; Institute of Food Safety and Nutrition, Jinan University, Guangzhou 510632, China, jianboxiao@jnu.edu.cnnone
local.edoc.affiliationGuo, Zhiming; School of Food and Biological Engineering, Jiangsu University, Zhenjiang 212013, China, guozhiming@ujs.edu.cnnone
local.edoc.affiliationEl-Seedi, Hesham R.; Department of Chemistry, Faculty of Science, Menoufia University, Shebin El-Kom 32512, Egypt, hesham.el-seedi@farmbio.uu.se International Research Center for Food Nutrition and Safety, Jiangsu University, Zhenjiang 212013, China, hesham.el-seedi@farmbio.uu.se; Pharmacognosy Group, Department of Pharmaceutical Biosciences, Uppsala University, Biomedical Centre, P.O. Box 574, SE-751 23 Uppsala, Sweden, hesham.el-seedi@farmbio.uu.senone

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