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2021-10-21Zeitschriftenartikel DOI: 10.3390/pharmaceutics13111759
A Comprehensive Review about the Molecular Structure of Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2): Insights into Natural Products against COVID-19
dc.contributor.authorSaied, Essa M.
dc.contributor.authorEl-Maradny , Yousra
dc.contributor.authorOsman, Alaa A.
dc.contributor.authorDarwish, Amira
dc.contributor.authorAbo Nahas, Hebatallah H.
dc.contributor.authorNiedbała, Gniewko
dc.contributor.authorPiekutowska, Magdalena
dc.contributor.authorAbdel-Rahman, Mohamed
dc.contributor.authorBalbool, Bassem
dc.contributor.authorAbdel-Azeem, Ahmed
dc.contributor.editorDe Rosa, Giuseppe
dc.date.accessioned2021-11-09T12:44:49Z
dc.date.available2021-11-09T12:44:49Z
dc.date.issued2021-10-21none
dc.date.updated2021-11-05T01:43:51Z
dc.identifier.urihttp://edoc.hu-berlin.de/18452/24310
dc.description.abstractIn 2019, the world suffered from the emergence of COVID-19 infection, one of the most difficult pandemics in recent history. Millions of confirmed deaths from this pandemic have been reported worldwide. This disaster was caused by SARS-CoV-2, which is the last discovered member of the family of Coronaviridae. Various studies have shown that natural compounds have effective antiviral properties against coronaviruses by inhibiting multiple viral targets, including spike proteins and viral enzymes. This review presents the classification and a detailed explanation of the SARS-CoV-2 molecular characteristics and structure–function relationships. We present all currently available crystal structures of different SARS-CoV-2 proteins and emphasized on the crystal structure of different virus proteins and the binding modes of their ligands. This review also discusses the various therapeutic approaches for COVID-19 treatment and available vaccinations. In addition, we highlight and compare the existing data about natural compounds extracted from algae, fungi, plants, and scorpion venom that were used as antiviral agents against SARS-CoV-2 infection. Moreover, we discuss the repurposing of select approved therapeutic agents that have been used in the treatment of other viruses.eng
dc.language.isoengnone
dc.publisherHumboldt-Universität zu Berlin
dc.rights(CC BY 4.0) Attribution 4.0 Internationalger
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/
dc.subjectcoronaviruseng
dc.subjectSARS-CoV-2eng
dc.subjectvirus lifecycleeng
dc.subjectCOVID-19eng
dc.subjectvirus detectioneng
dc.subjectmolecular structureeng
dc.subjectvaccineseng
dc.subjecttherapeutic approacheng
dc.subjectnatural productseng
dc.subjectantiviralseng
dc.subjectantioxidantseng
dc.subject.ddc610 Medizin und Gesundheitnone
dc.titleA Comprehensive Review about the Molecular Structure of Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2): Insights into Natural Products against COVID-19none
dc.typearticle
dc.identifier.urnurn:nbn:de:kobv:11-110-18452/24310-4
dc.identifier.doi10.3390/pharmaceutics13111759none
dc.identifier.doihttp://dx.doi.org/10.18452/23649
dc.type.versionpublishedVersionnone
local.edoc.container-titlePharmaceuticsnone
local.edoc.pages50none
local.edoc.type-nameZeitschriftenartikel
local.edoc.institutionMathematisch-Naturwissenschaftliche Fakultätnone
local.edoc.container-typeperiodical
local.edoc.container-type-nameZeitschrift
local.edoc.container-publisher-nameMDPInone
local.edoc.container-publisher-placeBaselnone
local.edoc.container-volume13none
local.edoc.container-issue11none
dc.description.versionPeer Reviewednone
local.edoc.container-articlenumber1759none
dc.identifier.eissn1999-4923
local.edoc.affiliationSaied, Essa M.; 1Chemistry Department, Faculty of Science, Suez Canal University, Ismailia 41522, Egyptnone
local.edoc.affiliationEl-Maradny, Yousra A.; 3Microbiology Department, High Institute of Public Health, Alexandria University, Alexandria 21526, Egypt; hiph.ymaradny@alexu.edu.egnone
local.edoc.affiliationOsman, Alaa A.; 4Department of Pharmaceutical Chemistry, Faculty of Pharmacy, New Giza University, Newgiza, km 22 Cairo–Alexandria Desert Road, Cairo 12256, Egypt; ala.awad@ngu.edu.egnone
local.edoc.affiliationDarwish, Amira M. G.; 5Food Technology Department, Arid Lands Cultivation Research Institute (ALCRI), City of Scientific Research and Technological Applications (SRTA City), Alexandria 21934, Egypt; amiragdarwish@yahoo.comnone
local.edoc.affiliationAbo Nahas, Hebatallah H.; 6Zoology Department, Faculty of Science, Suez Canal University, Ismailia 41522, Egypt; hebatallah_hassan@science.suez.edu.eg (H.H.A.N.); mohamed_hassanain@science.suez.edu.eg (M.A.A.-R.)none
local.edoc.affiliationNiedbała, Gniewko; 7Department of Biosystems Engineering, Faculty of Environmental and Mechanical Engineering, Poznań University of Life Sciences, Wojska Polskiego 50, 60-627 Poznań, Poland; gniewko.niedbala@up.poznan.plnone
local.edoc.affiliationPiekutowska, Magdalena; 8Department of Geoecology and Geoinformation, Institute of Biology and Earth Sciences, Pomeranian University in Słupsk, Partyzantów 27, 76-200 Słupsk, Poland; magdalena.piekutowska@apsl.edu.plnone
local.edoc.affiliationAbdel-Rahman, Mohamed A.; 6Zoology Department, Faculty of Science, Suez Canal University, Ismailia 41522, Egypt; hebatallah_hassan@science.suez.edu.eg (H.H.A.N.); mohamed_hassanain@science.suez.edu.eg (M.A.A.-R.)none
local.edoc.affiliationBalbool, Bassem A.; 9Faculty of Biotechnology, October University for Modern Sciences and Arts, Giza 12585, Egypt; Bbalbool@msa.edu.egnone
local.edoc.affiliationAbdel-Azeem, Ahmed M.; 10Botany and Microbiology Department, Faculty of Science, Suez Canal University, Ismailia 41522, Egyptnone

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