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2020-09-05Zeitschriftenartikel DOI: 10.18452/24077
Zyklische Dinukleotide als molekulare Entwicklungsbremse
Wörmann, Mirka E.
Tschowri, Natalia cc
Mathematisch-Naturwissenschaftliche Fakultät
Streptomyces are renowned producers of antibiotics and other medically useful molecules. They undergo a developmental life cycle involving progression from vegetative growth to the erection of reproductive aerial hyphae, which differentiate into chains of spores. The second messengers c-di-GMP and c-di-AMP control this complex morphological transition. Studies on signalling mechanisms in this bacterial model led to the discovery of a tetrameric c-di-GMP, a sigma factor as an unexpected type of c-di-GMP effectors and a new class of c-di-AMP phosphodiesterases.
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DOI
10.18452/24077
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