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2021-06-30Zeitschriftenartikel DOI: 10.18452/24234
Shapes of cell signaling
dc.contributor.authorLinding, Rune
dc.contributor.authorKlipp, Edda
dc.date.accessioned2022-03-01T14:33:25Z
dc.date.available2022-03-01T14:33:25Z
dc.date.issued2021-06-30none
dc.identifier.other10.1016/j.coisb.2021.100354
dc.identifier.urihttp://edoc.hu-berlin.de/18452/24897
dc.description.abstractCell signaling is a complex process organized in time and space. Signal transduction is constantly modulated by cell-intrinsic and cell-extrinsic input cues and the resulting phenotypic responses such as morphological can feed back into the system. This provides cells with a responsive, accurate, and rugged system to deal with changes in the surroundings or the genome. Whilst signaling networks (dynamic transient protein–protein interactions modulated by post-translational modifications in response to input cues) have been researched for decades, further analysis of their spatial organization is critical for both basic and disease biology and will benefit from recent advances in computational modeling and image analysis using deep/machine learning and in microscopy and imaging. Furthermore, mathematical modeling with reaction-diffusion approaches on time-varying geometries complements the investigations, allowing to conceptualize the organizational principles of signaling and information transduction in the four dimensions of time and space.eng
dc.language.isoengnone
dc.publisherHumboldt-Universität zu Berlin
dc.rights(CC BY 4.0) Attribution 4.0 Internationalger
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/
dc.subjectSignaling in contexteng
dc.subjectCell shapeeng
dc.subjectDeep hidden physicseng
dc.subjectReaction-diffusion systemseng
dc.subjectCell morphologyeng
dc.subjectComplex diseaseseng
dc.subject.ddc570 Biologienone
dc.titleShapes of cell signalingnone
dc.typearticle
dc.identifier.urnurn:nbn:de:kobv:11-110-18452/24897-4
dc.identifier.doihttp://dx.doi.org/10.18452/24234
dc.type.versionpublishedVersionnone
local.edoc.container-titleCurrent Opinion in Systems Biologynone
local.edoc.pages7none
local.edoc.type-nameZeitschriftenartikel
local.edoc.institutionLebenswissenschaftliche Fakultätnone
local.edoc.container-typeperiodical
local.edoc.container-type-nameZeitschrift
local.edoc.container-publisher-nameElseviernone
local.edoc.container-publisher-placeAmsterdamnone
local.edoc.container-issue2021, 27none
dc.description.versionPeer Reviewednone
local.edoc.container-articlenumber100354
dc.identifier.eissn2452-3100

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