Browsing Artikel und Monographien by Author "Ochtrop, Philipp"

Now showing items 1-2 of 2

2022-08-22Zeitschriftenartikel

DFT‐Guided Discovery of Ethynyl‐Triazolyl‐Phosphinates as Modular Electrophiles for Chemoselective Cysteine Bioconjugation and Profiling

Stieger, Christian; Park, Yerin; de Geus, Mark; Kim, Dongju; Huhn, Christiane; Slenczka, J. Sophia; Ochtrop, Philipp; Müchler, Judith M.; Süssmuth, Roderich; Broichhagen, Johannes; Baik, Mu-Hyun; Hackenberger, Christian

We report the density functional theory (DFT) guided discovery of ethynyl‐triazolyl‐phosphinates (ETPs) as a new class of electrophilic warheads for cysteine selective bioconjugation. By using CuI‐catalysed azide alkyne ...
2020-11-18Zeitschriftenartikel

Site‐Specific Antibody Fragment Conjugates for Reversible Staining in Fluorescence Microscopy

Schwach, Jonathan; Kolobynina, Ksenia; Brandstetter, Katharina; Gerlach, Marcus; Ochtrop, Philipp; Helma, Jonas; Hackenberger, Christian; Harz, Hartmann; Cardoso, M. Cristina; Leonhardt, Heinrich; Stengl, Andreas

Antibody conjugates have taken a great leap forward as tools in basic and applied molecular life sciences that was enabled by the development of chemoselective reactions for the site‐specific modification of proteins. ...