2021-06-17Zeitschriftenartikel
Phosphorylation and O-GlcNAcylation of the PHF-1 Epitope of Tau Protein Induce Local Conformational Changes of the C-Terminus and Modulate Tau Self-Assembly Into Fibrillar Aggregates
Cantrelle, François-Xavier; Loyens, Anne; Trivelli, Xavier; Reimann, Oliver; Despres, Clément; Gandhi, Neha; Hackenberger, Christian; Landrieu, Isabelle; Smet-Nocca, Caroline
Phosphorylation of the neuronal microtubule-associated Tau protein plays a critical role in the aggregation process leading to the formation of insoluble intraneuronal fibrils within Alzheimer’s disease (AD) brains. In ...
