Show simple item record

2020-06-26Zeitschriftenartikel DOI: 10.3390/electronics9061056
Photostimulation of Extravasation of Beta-Amyloid through the Model of Blood-Brain Barrier
dc.contributor.authorZinchenko, Ekaterina
dc.contributor.authorKlimova, Maria
dc.contributor.authorMamedova, Aysel
dc.contributor.authorAgranovich, Ilana
dc.contributor.authorBlokhina, Inna
dc.contributor.authorAntonova, Tatiana
dc.contributor.authorTerskov, Andrey
dc.contributor.authorShirokov, Alexander
dc.contributor.authorNavolokin, Nikita
dc.contributor.authorMorgun, Andrey
dc.contributor.authorOsipova, Elena
dc.contributor.authorBoytsova, Elizaveta
dc.contributor.authorYu, Tingting
dc.contributor.authorZhu, Dan
dc.contributor.authorKurths, Jürgen
dc.contributor.authorSemyachkina-Glushkovskaya, Oxana
dc.date.accessioned2022-05-19T11:36:39Z
dc.date.available2022-05-19T11:36:39Z
dc.date.issued2020-06-26none
dc.date.updated2020-07-12T02:41:12Z
dc.identifier.urihttp://edoc.hu-berlin.de/18452/25349
dc.description.abstractAlzheimer’s disease (AD) is an incurable pathology associated with progressive decline in memory and cognition. Phototherapy might be a new promising and alternative strategy for the effective treatment of AD, and has been actively discussed over two decades. However, the mechanisms of therapeutic photostimulation (PS) effects on subjects with AD remain poorly understood. The goal of this study was to determine the mechanisms of therapeutic PS effects in beta-amyloid (Aβ)-injected mice. The neurological severity score and the new object recognition tests demonstrate that PS 9 J/cm2 attenuates the memory and neurological deficit in mice with AD. The immunohistochemical assay revealed a decrease in the level of Aβ in the brain and an increase of Aβ in the deep cervical lymph nodes obtained from mice with AD after PS. Using the in vitro model of the blood-brain barrier (BBB), we show a PS-mediated decrease in transendothelial resistance and in the expression of tight junction proteins as well an increase in the BBB permeability to Aβ. These findings suggest that a PS-mediated BBB opening and the activation of the lymphatic clearance of Aβ from the brain might be a crucial mechanism underlying therapeutic effects of PS in mice with AD. These pioneering data open new strategies in the development of non-pharmacological methods for therapy of AD and contribute to a better understanding of the PS effects on the central nervous system.eng
dc.description.sponsorshipRussian Science Foundation
dc.description.sponsorshipRussian Foundation for Fundamental Investigations
dc.language.isoengnone
dc.publisherHumboldt-Universität zu Berlin
dc.rights(CC BY 4.0) Attribution 4.0 Internationalger
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/
dc.subjectAlzheimer’s diseaseeng
dc.subjecttranscranialphotostimulationeng
dc.subjectlymphatic systemeng
dc.subjectblood-brain barriereng
dc.subject.ddc530 Physiknone
dc.titlePhotostimulation of Extravasation of Beta-Amyloid through the Model of Blood-Brain Barriernone
dc.typearticle
dc.identifier.urnurn:nbn:de:kobv:11-110-18452/25349-2
dc.identifier.doi10.3390/electronics9061056none
dc.identifier.doihttp://dx.doi.org/10.18452/24684
dc.type.versionpublishedVersionnone
local.edoc.container-titleElectronicsnone
local.edoc.pages12none
local.edoc.type-nameZeitschriftenartikel
local.edoc.institutionMathematisch-Naturwissenschaftliche Fakultätnone
local.edoc.container-typeperiodical
local.edoc.container-type-nameZeitschrift
local.edoc.container-publisher-nameMDPInone
local.edoc.container-publisher-placeBaselnone
local.edoc.container-volume9none
local.edoc.container-issue6none
dc.description.versionPeer Reviewednone
local.edoc.container-articlenumber1056none
dc.identifier.eissn2079-9292

Show simple item record