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2022-03-18Zeitschriftenartikel DOI: 10.18452/24895
Safety and Tolerability of Accelerated Low-Frequency Repetitive Transcranial Magnetic Stimulation Over the Primary Motor Cortex–A Pilot Study
dc.contributor.authorEngelhardt, Melina
dc.contributor.authorKimmel, Jana
dc.contributor.authorRaffa, Giovanni
dc.contributor.authorConti, Alfredo
dc.contributor.authorPicht, Thomas
dc.date.accessioned2022-06-30T12:56:58Z
dc.date.available2022-06-30T12:56:58Z
dc.date.issued2022-03-18none
dc.date.updated2022-04-26T11:46:16Z
dc.identifier.urihttp://edoc.hu-berlin.de/18452/25578
dc.description.abstractLow-frequency repetitive transcranial magnetic stimulation (rTMS) is capable of inducing changes in the functional organization of underlying brain regions, however, often at the cost of long stimulation protocols over several weeks. As these protocols can be difficult to implement in clinical settings, the aim of the present pilot study was to show the feasibility and safety of an accelerated low-frequency rTMS protocol applying multiple sessions daily. To this purpose, nine healthy subjects received 14 sessions of rTMS (1 Hz, 30 min, 110% RMT) to the hand motor hotspot. Subjects received stimulation for either 14 days once daily [classical rTMS (c-rTMS)], 7 days twice daily (accelerated rTMS; a-rTMS), or sham stimulation for 14 days once daily (s-rTMS). Daily stimulation sessions in the a-rTMS group were delivered with a 90-min break in between. In total, 74% of rTMS sessions in the c-rTMS group, 89% in the a-rTMS group, and 98% in the s-rTMS group were free of any side effects. Brief headaches and fatigue in stimulated muscle groups were the most frequent side effects. All side effects were reported to be at maximum mild and of short duration. Thus, accelerated low-frequency rTMS of the motor cortex seems to be a safe and feasible method, previously shown to induce a functional reorganization of the motor system. By shortening treatment duration in days, this approach can potentially make rTMS protocols more accessible to a wider range of patients.eng
dc.language.isoengnone
dc.publisherHumboldt-Universität zu Berlin
dc.rights(CC BY 4.0) Attribution 4.0 Internationalger
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/
dc.subjecttranscranial magnetic stimulationeng
dc.subjectneuromodulationeng
dc.subjectacceleratedeng
dc.subjectlow-frequencyeng
dc.subjectmotor cortexeng
dc.subject.ddc610 Medizin und Gesundheitnone
dc.titleSafety and Tolerability of Accelerated Low-Frequency Repetitive Transcranial Magnetic Stimulation Over the Primary Motor Cortex–A Pilot Studynone
dc.typearticle
dc.identifier.urnurn:nbn:de:kobv:11-110-18452/25578-3
dc.identifier.doihttp://dx.doi.org/10.18452/24895
dc.type.versionpublishedVersionnone
local.edoc.pages5none
local.edoc.type-nameZeitschriftenartikel
local.edoc.container-typeperiodical
local.edoc.container-type-nameZeitschrift
dc.description.versionPeer Reviewednone
dc.identifier.eissn1662-453X
dcterms.bibliographicCitation.doi10.3389/fnins.2022.793742none
dcterms.bibliographicCitation.journaltitleFrontiers in neurosciencenone
dcterms.bibliographicCitation.volume16none
dcterms.bibliographicCitation.articlenumber793742none
dcterms.bibliographicCitation.originalpublishernameFrontiers Research Foundationnone
dcterms.bibliographicCitation.originalpublisherplaceLausannenone
bua.departmentCluster im Rahmen der Exzellenzinitiativenone

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