Show simple item record

2019-11-12Zeitschriftenartikel DOI: 10.18452/24938
Cue‐induced effects on decision‐making distinguish subjects with gambling disorder from healthy controls
dc.contributor.authorGenauck, Alexander
dc.contributor.authorAndrejevic, Milan
dc.contributor.authorBrehm, Katharina
dc.contributor.authorMatthis, Caroline
dc.contributor.authorHeinz, Andreas
dc.contributor.authorWeinreich, André
dc.contributor.authorKathmann, Norbert
dc.contributor.authorRomanczuk-Seiferth, Nina
dc.date.accessioned2022-07-05T13:54:01Z
dc.date.available2022-07-05T13:54:01Z
dc.date.issued2019-11-12none
dc.date.updated2020-10-12T09:54:37Z
dc.identifier.urihttp://edoc.hu-berlin.de/18452/25620
dc.description.abstractWhile an increased impact of cues on decision‐making has been associated with substance dependence, it is yet unclear whether this is also a phenotype of non‐substance‐related addictive disorders, such as gambling disorder (GD). To better understand the basic mechanisms of impaired decision‐making in addiction, we investigated whether cue‐induced changes in decision‐making could distinguish GD from healthy control (HC) subjects. We expected that cue‐induced changes in gamble acceptance and specifically in loss aversion would distinguish GD from HC subjects. Thirty GD subjects and 30 matched HC subjects completed a mixed gambles task where gambling and other emotional cues were shown in the background. We used machine learning to carve out the importance of cue dependency of decision‐making and of loss aversion for distinguishing GD from HC subjects. Cross‐validated classification yielded an area under the receiver operating curve (AUC‐ROC) of 68.9% (p = .002). Applying the classifier to an independent sample yielded an AUC‐ROC of 65.0% (p = .047). As expected, the classifier used cue‐induced changes in gamble acceptance to distinguish GD from HC. Especially, increased gambling during the presentation of gambling cues characterized GD subjects. However, cue‐induced changes in loss aversion were irrelevant for distinguishing GD from HC subjects. To our knowledge, this is the first study to investigate the classificatory power of addiction‐relevant behavioral task parameters when distinguishing GD from HC subjects. The results indicate that cue‐induced changes in decision‐making are a characteristic feature of addictive disorders, independent of a substance of abuseeng
dc.description.sponsorshipDeutsche Forschungsgemeinschaft http://dx.doi.org/10.13039/501100001659
dc.description.sponsorshipSenatsverwaltung für Gesundheit, Pflege und Gleichstellung, Berlin
dc.language.isoengnone
dc.publisherHumboldt-Universität zu Berlin
dc.rights(CC BY 4.0) Attribution 4.0 Internationalger
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/
dc.subjectdecision‐makingeng
dc.subjectgambling disordereng
dc.subjectloss aversioneng
dc.subjectPavlovian‐to‐instrumental transfereng
dc.subject.ddc150 Psychologienone
dc.titleCue‐induced effects on decision‐making distinguish subjects with gambling disorder from healthy controlsnone
dc.typearticle
dc.identifier.urnurn:nbn:de:kobv:11-110-18452/25620-3
dc.identifier.doihttp://dx.doi.org/10.18452/24938
dc.type.versionpublishedVersionnone
local.edoc.pages10none
local.edoc.type-nameZeitschriftenartikel
local.edoc.container-typeperiodical
local.edoc.container-type-nameZeitschrift
dc.description.versionPeer Reviewednone
dcterms.bibliographicCitation.doi10.1111/adb.12841none
dcterms.bibliographicCitation.journaltitleAddiction Biologynone
dcterms.bibliographicCitation.originalpublishernameWiley-Blackwellnone
dcterms.bibliographicCitation.originalpublisherplaceHoboken, NJ [u.a.]none
bua.departmentLebenswissenschaftliche Fakultätnone

Show simple item record