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2021-03-26Zeitschriftenartikel DOI: 10.1002/adfm.202009003
Graphene‐Assisted Synthesis of 2D Polyglycerols as Innovative Platforms for Multivalent Virus Interactions
dc.contributor.authorMohammadifar, Ehsan
dc.contributor.authorAhmadi, Vahid
dc.contributor.authorGholami, Mohammad Fardin
dc.contributor.authorOehrl, Alexander
dc.contributor.authorKolyvushko, Oleksandr
dc.contributor.authorNie, Chuanxiong
dc.contributor.authorDonskyi, Ievgen
dc.contributor.authorHerziger, Svenja
dc.contributor.authorRadnik, Joerg
dc.contributor.authorLudwig, Kai
dc.contributor.authorBöttcher, Christoph
dc.contributor.authorRabe, Jürgen P.
dc.contributor.authorOsterrieder, Nikolaus
dc.contributor.authorAzab, Walid
dc.contributor.authorHaag, Rainer
dc.contributor.authorAdeli, Mohsen
dc.date.accessioned2022-08-11T09:33:20Z
dc.date.available2022-08-11T09:33:20Z
dc.date.issued2021-03-26none
dc.date.updated2021-06-01T10:22:45Z
dc.identifier.urihttp://edoc.hu-berlin.de/18452/25809
dc.description.abstract2D nanomaterials have garnered widespread attention in biomedicine and bioengineering due to their unique physicochemical properties. However, poor functionality, low solubility, intrinsic toxicity, and nonspecific interactions at biointerfaces have hampered their application in vivo. Here, biocompatible polyglycerol units are crosslinked in two dimensions using a graphene-assisted strategy leading to highly functional and water-soluble polyglycerols nanosheets with 263 ± 53 nm and 2.7 ± 0.2 nm average lateral size and thickness, respectively. A single-layer hyperbranched polyglycerol containing azide functional groups is covalently conjugated to the surface of a functional graphene template through pH-sensitive linkers. Then, lateral crosslinking of polyglycerol units is carried out by loading tripropargylamine on the surface of graphene followed by lifting off this reagent for an on-face click reaction. Subsequently, the polyglycerol nanosheets are detached from the surface of graphene by slight acidification and centrifugation and is sulfated to mimic heparin sulfate proteoglycans. To highlight the impact of the two-dimensionality of the synthesized polyglycerol sulfate nanosheets at nanobiointerfaces, their efficiency with respect to herpes simplex virus type 1 and severe acute respiratory syndrome corona virus 2 inhibition is compared to their 3D nanogel analogs. Four times stronger in virus inhibition suggests that 2D polyglycerols are superior to their current 3D counterparts.eng
dc.language.isoengnone
dc.publisherHumboldt-Universität zu Berlin
dc.rights(CC BY-NC 4.0) Attribution-NonCommercial 4.0 Internationalger
dc.rights.urihttps://creativecommons.org/licenses/by-nc/4.0/
dc.subject2D materialseng
dc.subjectgraphene templateeng
dc.subjectmultivalencyeng
dc.subjectpolyglyceroleng
dc.subjectvirus inhibitioneng
dc.subject.ddc620 Ingenieurwissenschaften und zugeordnete Tätigkeitennone
dc.subject.ddc540 Chemie und zugeordnete Wissenschaftennone
dc.subject.ddc530 Physiknone
dc.titleGraphene‐Assisted Synthesis of 2D Polyglycerols as Innovative Platforms for Multivalent Virus Interactionsnone
dc.typearticle
dc.identifier.urnurn:nbn:de:kobv:11-110-18452/25809-7
dc.identifier.doi10.1002/adfm.202009003none
dc.identifier.doihttp://dx.doi.org/10.18452/25123
dc.type.versionpublishedVersionnone
local.edoc.container-titleAdvanced Functional Materialsnone
local.edoc.pages11none
local.edoc.type-nameZeitschriftenartikel
local.edoc.institutionMathematisch-Naturwissenschaftliche Fakultätnone
local.edoc.container-typeperiodical
local.edoc.container-type-nameZeitschrift
local.edoc.container-publisher-nameWiley-VCHnone
local.edoc.container-publisher-placeWeinheimnone
local.edoc.container-volume31none
local.edoc.container-issue22none
dc.description.versionPeer Reviewednone
local.edoc.container-articlenumber2009003none
dc.identifier.eissn1616-3028

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