Show simple item record

2021-11-02Zeitschriftenartikel DOI: 10.3390/app112110287
A Novel Method to Stimulate Lymphatic Clearance of Beta-Amyloid from Mouse Brain Using Noninvasive Music-Induced Opening of the Blood–Brain Barrier with EEG Markers
dc.contributor.authorSemyachkina-Glushkovskaya, Oxana
dc.contributor.authorKhorovodov, Alexander
dc.contributor.authorFedosov, Ivan
dc.contributor.authorPavlov, Alexey
dc.contributor.authorShirokov, Alexander
dc.contributor.authorSharif, Ali Esmat
dc.contributor.authorDubrovsky, Alexander
dc.contributor.authorBlokhina, Inna
dc.contributor.authorTerskov, Andrey
dc.contributor.authorNavolokin, Nikita
dc.contributor.authorEvsukova, Arina
dc.contributor.authorKarandin, Georgy
dc.contributor.authorElovenko, Dariya
dc.contributor.authorTzoy, Maria
dc.contributor.authorAgeev, Vasily
dc.contributor.authorAgranovich, Ilana
dc.contributor.authorTelnova, Valeriya
dc.contributor.authorTsven, Anna
dc.contributor.authorSaranceva, Elena
dc.contributor.authorIskra, Tatyana
dc.contributor.authorKurths, Jürgen
dc.date.accessioned2022-08-11T12:33:56Z
dc.date.available2022-08-11T12:33:56Z
dc.date.issued2021-11-02none
dc.date.updated2021-12-01T14:46:41Z
dc.identifier.urihttp://edoc.hu-berlin.de/18452/25815
dc.description.abstractThe lymphatic system of the brain meninges and head plays a crucial role in the clearance of amyloid-β protein (Aβ), a peptide thought to be pathogenic in Alzheimer’s disease (AD), from the brain. The development of methods to modulate lymphatic clearance of Aβ from the brain coild be a revolutionary step in the therapy of AD. The opening of the blood–brain barrier (OBBB) by focused ultrasound is considered as a possible tool for stimulation of clearance of Aβ from the brain of humans and animals. Here, we propose an alternative method of noninvasive music-induced OBBB that is accompanied by the activation of clearance of fluorescent Aβ (Fαβ) from the mouse brain. Using confocal imaging, fluorescence microscopy, and magnetic resonance tomography, we clearly demonstrate that OBBB by music stimulates the movement of Fαβ and Omniscan in the cerebrospinal fluid and lymphatic clearance of Fαβ from the brain. We propose the extended detrended fluctuation analysis (EDFA) as a promising method for the identification of OBBB markers in the electroencephalographic (EEG) patterns. These pilot results suggest that music-induced OBBB and the EDFA analysis of EEG can be a noninvasive, low-cost, labeling-free, clinical perspective and completely new approach for the treatment and monitoring of AD.eng
dc.language.isoengnone
dc.publisherHumboldt-Universität zu Berlin
dc.rights(CC BY 4.0) Attribution 4.0 Internationalger
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/
dc.subjectmusiceng
dc.subjectblood–brain barriereng
dc.subjectlymphatic systemeng
dc.subjectamyloid-β proteineng
dc.subjectdetrended fluctuation analysiseng
dc.subjectelectroencephalographic patternseng
dc.subject.ddc600 Technik und Technologienone
dc.titleA Novel Method to Stimulate Lymphatic Clearance of Beta-Amyloid from Mouse Brain Using Noninvasive Music-Induced Opening of the Blood–Brain Barrier with EEG Markersnone
dc.typearticle
dc.identifier.urnurn:nbn:de:kobv:11-110-18452/25815-8
dc.identifier.doi10.3390/app112110287none
dc.identifier.doihttp://dx.doi.org/10.18452/25129
dc.type.versionpublishedVersionnone
local.edoc.container-titleApplied Sciencesnone
local.edoc.pages13none
local.edoc.type-nameZeitschriftenartikel
local.edoc.institutionMathematisch-Naturwissenschaftliche Fakultätnone
local.edoc.container-typeperiodical
local.edoc.container-type-nameZeitschrift
local.edoc.container-publisher-nameMDPInone
local.edoc.container-publisher-placeBaselnone
local.edoc.container-volume11none
local.edoc.container-issue21none
dc.description.versionPeer Reviewednone
local.edoc.container-articlenumber10287none
dc.identifier.eissn2076-3417

Show simple item record