Now showing items 141-150 of 172
Rational Design of a DNA-Scaffolded High-Affinity Binder for Langerin
Binders of langerin could target vaccines to Langerhans cells for improved therapeutic effect. Since langerin has low affinity for monovalent glycan ligands, highly multivalent presentation has previously been key for ...
Liposomal FRET Assay Identifies Potent Drug‐Like Inhibitors of the Ceramide Transport Protein (CERT)
Ceramide transfer protein (CERT) mediates non‐vesicular transfer of ceramide from endoplasmic reticulum to Golgi apparatus and thus catalyzes the rate‐limiting step of sphingomyelin biosynthesis. Usually, CERT ligands are ...
Site‐Specific Antibody Fragment Conjugates for Reversible Staining in Fluorescence Microscopy
Antibody conjugates have taken a great leap forward as tools in basic and applied molecular life sciences that was enabled by the development of chemoselective reactions for the site‐specific modification of proteins. ...
Synthesis, Characterization, and Reactivity of a Series of Homo‐ and Hetero‐dinuclear Complexes based on an Asymmetric FloH Ligand System
In a previous communication we reported the site‐directed generation of a heterodinuclear FeIIICuII complex (1 ) by using an asymmetric dinucleating ligand FloH. The iron(III) ion was introduced first on the preferential ...
Enhancing Tris(pyrazolyl)borate-Based Models of Cysteine/ Cysteamine Dioxygenases through Steric Effects
Increased Reactivities, Full Product Characterization and Hints to Initial Superoxide Formation
The design of biomimetic model complexes for the cysteine dioxygenase (CDO) and cysteamine dioxygenase (ADO) is reported, where the 3‐His coordination of the iron ion is simulated by three pyrazole donors of a trispyrazolyl ...
Redox Potentials of High‐Valent Iron‐, Cobalt‐, and Nickel‐Oxido Complexes: Evidence for Exchange Enhanced Reactivity
The ferrocene titration method has been employed to determine the one‐electron reduction potentials of a series of oxido‐iron(IV), oxido‐cobalt(IV) and oxido/hydroxido‐nickel(III) complexes based on the same tetradentate ...
Machine Learning in Computational Surface Science and Catalysis: Case Studies on Water and Metal–Oxide Interfaces
The goal of many computational physicists and chemists is the ability to bridge the gap between atomistic length scales of about a few multiples of an Ångström (Å), i. e., 10−10 m, and meso- or macroscopic length scales ...
Structure and properties of fluorinated and non‐fluorinated Ba‐coordination polymers – the position of fluorine makes the difference
As the most electronegative element, fluorine has a strong influence on material properties such as absorption behaviour or chemical and thermal stability. Fluorine can be easily integrated into coordination polymers (CPs) ...
Strategies for Site‐Specific Labeling of Receptor Proteins on the Surfaces of Living Cells by Using Genetically Encoded Peptide Tags
Fluorescence microscopy imaging enables receptor proteins to be investigated within their biological context. A key challenge is to site-specifically incorporate reporter moieties into proteins without interfering with ...