Now showing items 1-10 of 10
A Novel Visible Range FRET Probe for Monitoring Acid Sphingomyelinase Activity in Living Cells
Activity of acid sphingomyelinase has been implicated in a number of diseases like acute lung injury, sepsis or metastasis of melanoma cells. Here, we present a sphingomyelinase FRET probe based on FAM/BODIPY dyes for ...
A π‐Conjugated, Covalent Phosphinine Framework
Structural modularity of polymer frameworks is a key advantage of covalent organic polymers, however, only C, N, O, Si, and S have found their way into their building blocks so far. Here, the toolbox available to polymer ...
Oxygen-Depleted Calixarenes as Ligands for Molecular Models of Galactose Oxidase
A calixarene ligand, in which two of the phenol functions are replaced by pyrazole units has been employed to mimic the His2–Tyr2 (His: histidine, Tyr: tyrosine) ligand sphere within the active site of the galactose ...
Mechanistic Insights into the Triplet Sensitized Photochromism of Diarylethenes
Operating photoswitchable molecules repetitively and reliably is crucial for most of their applications, in particular in (opto)electronic devices, and related to reversibility and fatigue resistance, which both critically ...
Molecular Bottle Brushes with Positioned Selenols
Extending the Toolbox of Oxidative Single Polymer Chain Folding with Conformation Analysis by Atomic Force Microscopy
A synthesis route to controlled and dynamic single polymer chain folding is reported. Sequence‐controlled macromolecules containing precisely located selenol moieties within a polymer chain are synthesized. Oxidation of ...
Enhancing Tris(pyrazolyl)borate-Based Models of Cysteine/ Cysteamine Dioxygenases through Steric Effects
Increased Reactivities, Full Product Characterization and Hints to Initial Superoxide Formation
The design of biomimetic model complexes for the cysteine dioxygenase (CDO) and cysteamine dioxygenase (ADO) is reported, where the 3‐His coordination of the iron ion is simulated by three pyrazole donors of a trispyrazolyl ...
A Pseudotetrahedral Terminal Oxoiron(IV) Complex: Mechanistic Promiscuity in C−H Bond Oxidation Reactions
S=2 oxoiron(IV) species act as reactive intermediates in the catalytic cycle of nonheme iron oxygenases. The few available synthetic S=2 FeIV=O complexes known to date are often limited to trigonal bipyramidal and very ...
Accessing the Next Generation of Synthetic Mussel‐Glue Polymers via Mussel‐Inspired Polymerization
The formation of cysteinyldopa as biogenic connectivity in proteins is used to inspire a chemical pathway toward mussel-adhesive mimics. The mussel-inspired polymerization (MIPoly) exploits the chemically diverse family ...
Structural Determination of an Unusual CuI‐Porphyrin‐π‐Bond in a Hetero‐Pacman Cu‐Zn‐Complex
The synthesis and characterization of a hetero-dinuclear compound is presented, in which a copper(I)trishistidine type coordination unit is positioned directlyabove a zinc porphyrin unit. The close distance betweenthe two ...