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2020-08-31Zeitschriftenartikel DOI: 10.3390/ijms21176293
Sleep as a Novel Biomarker and a Promising Therapeutic Target for Cerebral Small Vessel Disease: A Review Focusing on Alzheimer’s Disease and the Blood-Brain Barrier
dc.contributor.authorSemyachkina-Glushkovskaya, Oxana
dc.contributor.authorPostnov, Dmitry
dc.contributor.authorPenzel, Thomas
dc.contributor.authorKurths, Jürgen
dc.date.accessioned2022-09-15T14:03:26Z
dc.date.available2022-09-15T14:03:26Z
dc.date.issued2020-08-31none
dc.date.updated2022-09-05T08:07:22Z
dc.identifier.urihttp://edoc.hu-berlin.de/18452/26004
dc.description.abstractCerebral small vessel disease (CSVD) is a leading cause of cognitive decline in elderly people and development of Alzheimer’s disease (AD). Blood–brain barrier (BBB) leakage is a key pathophysiological mechanism of amyloidal CSVD. Sleep plays a crucial role in keeping health of the central nervous system and in resistance to CSVD. The deficit of sleep contributes to accumulation of metabolites and toxins such as beta-amyloid in the brain and can lead to BBB disruption. Currently, sleep is considered as an important informative platform for diagnosis and therapy of AD. However, there are no effective methods for extracting of diagnostic information from sleep characteristics. In this review, we show strong evidence that slow wave activity (SWA) (0–0.5 Hz) during deep sleep reflects glymphatic pathology, the BBB leakage and memory deficit in AD. We also discuss that diagnostic and therapeutic targeting of SWA in AD might lead to be a novel era in effective therapy of AD. Moreover, we demonstrate that SWA can be pioneering non-invasive and bed–side technology for express diagnosis of the BBB permeability. Finally, we review the novel data about the methods of detection and enhancement of SWA that can be biomarker and a promising therapy of amyloidal CSVD and CSVD associated with the BBB disorders.eng
dc.description.sponsorshipRussian Science Foundation
dc.description.sponsorshipRussian Foundation for Basic Research
dc.description.sponsorshipMinistry of Science and Higher Education of the Russian Federation
dc.language.isoengnone
dc.publisherHumboldt-Universität zu Berlin
dc.rights(CC BY 4.0) Attribution 4.0 Internationalger
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/
dc.subjectCerebral small vessel diseaseeng
dc.subjectsleepeng
dc.subjectslow wave activityeng
dc.subjectAlzheimer's diseaseeng
dc.subjectblood-brain barriereng
dc.subject.ddc610 Medizin und Gesundheitnone
dc.titleSleep as a Novel Biomarker and a Promising Therapeutic Target for Cerebral Small Vessel Disease: A Review Focusing on Alzheimer’s Disease and the Blood-Brain Barriernone
dc.typearticle
dc.identifier.urnurn:nbn:de:kobv:11-110-18452/26004-6
dc.identifier.doi10.3390/ijms21176293none
dc.identifier.doihttp://dx.doi.org/10.18452/25311
dc.type.versionpublishedVersionnone
local.edoc.container-titleInternational journal of molecular sciencesnone
local.edoc.pages15none
local.edoc.type-nameZeitschriftenartikel
local.edoc.institutionMathematisch-Naturwissenschaftliche Fakultätnone
local.edoc.container-typeperiodical
local.edoc.container-type-nameZeitschrift
local.edoc.container-publisher-nameMolecular Diversity Preservation Internationalnone
local.edoc.container-publisher-placeBaselnone
local.edoc.container-volume21none
local.edoc.container-issue17none
dc.description.versionPeer Reviewednone
local.edoc.container-articlenumber6293none
dc.identifier.eissn1422-0067

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