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2018-11-30Zeitschriftenartikel DOI: 10.3390/ijms19123818
Blood−Brain Barrier, Lymphatic Clearance, and Recovery: Ariadne’s Thread in Labyrinths of Hypotheses
dc.contributor.authorSemyachkina-Glushkovskaya, Oxana
dc.contributor.authorPostnov, Dmitry
dc.contributor.authorKurths, Jürgen
dc.date.accessioned2022-09-15T14:16:27Z
dc.date.available2022-09-15T14:16:27Z
dc.date.issued2018-11-30none
dc.date.updated2022-09-05T08:11:04Z
dc.identifier.urihttp://edoc.hu-berlin.de/18452/26005
dc.description.abstractThe peripheral lymphatic system plays a crucial role in the recovery mechanisms after many pathological changes, such as infection, trauma, vascular, or metabolic diseases. The lymphatic clearance of different tissues from waste products, viruses, bacteria, and toxic proteins significantly contributes to the correspondent recovery processes. However, understanding of the cerebral lymphatic functions is a challenging problem. The exploration of mechanisms of lymphatic communication with brain fluids as well as the role of the lymphatic system in brain drainage, clearance, and recovery is still in its infancy. Here we review novel concepts on the anatomy and physiology of the lymphatics in the brain, which warrant a substantial revision of our knowledge about the role of lymphatics in the rehabilitation of the brain functions after neural pathologies. We discuss a new vision on the connective bridge between the opening of a blood–brain barrier and activation of the meningeal lymphatic clearance. The ability to stimulate the lymph flow in the brain, is likely to play an important role in developing future innovative strategies in neurorehabilitation therapy.eng
dc.description.sponsorshipRussian Science Foundation
dc.language.isoengnone
dc.publisherHumboldt-Universität zu Berlin
dc.rights(CC BY 4.0) Attribution 4.0 Internationalger
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/
dc.subjectperipheral and meningeal lymphaticseng
dc.subjectblood-brain barriereng
dc.subjectneurorehabilitationeng
dc.subject.ddc610 Medizin und Gesundheitnone
dc.titleBlood−Brain Barrier, Lymphatic Clearance, and Recovery: Ariadne’s Thread in Labyrinths of Hypothesesnone
dc.typearticle
dc.identifier.urnurn:nbn:de:kobv:11-110-18452/26005-2
dc.identifier.doi10.3390/ijms19123818none
dc.identifier.doihttp://dx.doi.org/10.18452/25312
dc.type.versionpublishedVersionnone
local.edoc.pages16none
local.edoc.type-nameZeitschriftenartikel
local.edoc.container-typeperiodical
local.edoc.container-type-nameZeitschrift
dc.description.versionPeer Reviewednone
dc.identifier.eissn1422-0067
dcterms.bibliographicCitation.journaltitleInternational journal of molecular sciencesnone
dcterms.bibliographicCitation.volume19none
dcterms.bibliographicCitation.issue12none
dcterms.bibliographicCitation.articlenumber3818none
dcterms.bibliographicCitation.originalpublishernameMolecular Diversity Preservation Internationalnone
dcterms.bibliographicCitation.originalpublisherplaceBaselnone
bua.departmentMathematisch-Naturwissenschaftliche Fakultätnone

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