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2018-09-26Zeitschriftenartikel DOI: 10.3390/ijms19102919
G Protein-Coupled Receptor Systems as Crucial Regulators of DNA Damage Response Processes
dc.contributor.authorLeysen, Hanne
dc.contributor.authorvan Gastel, Jaana
dc.contributor.authorHendrickx, Jhana
dc.contributor.authorSantos-Otte, Paula
dc.contributor.authorMartin, Bronwen
dc.contributor.authorMaudsley, Stuart
dc.date.accessioned2022-09-16T12:45:53Z
dc.date.available2022-09-16T12:45:53Z
dc.date.issued2018-09-26none
dc.date.updated2022-09-05T17:54:49Z
dc.identifier.urihttp://edoc.hu-berlin.de/18452/26022
dc.description.abstractG protein-coupled receptors (GPCRs) and their associated proteins represent one of the most diverse cellular signaling systems involved in both physiological and pathophysiological processes. Aging represents perhaps the most complex biological process in humans and involves a progressive degradation of systemic integrity and physiological resilience. This is in part mediated by age-related aberrations in energy metabolism, mitochondrial function, protein folding and sorting, inflammatory activity and genomic stability. Indeed, an increased rate of unrepaired DNA damage is considered to be one of the ‘hallmarks’ of aging. Over the last two decades our appreciation of the complexity of GPCR signaling systems has expanded their functional signaling repertoire. One such example of this is the incipient role of GPCRs and GPCR-interacting proteins in DNA damage and repair mechanisms. Emerging data now suggest that GPCRs could function as stress sensors for intracellular damage, e.g., oxidative stress. Given this role of GPCRs in the DNA damage response process, coupled to the effective history of drug targeting of these receptors, this suggests that one important future activity of GPCR therapeutics is the rational control of DNA damage repair systems.eng
dc.language.isoengnone
dc.publisherHumboldt-Universität zu Berlin
dc.rights(CC BY 4.0) Attribution 4.0 Internationalger
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/
dc.subjectG protein-coupled receptor (GPCR)eng
dc.subjectagingeng
dc.subjectDNA damageeng
dc.subjectβ-arrestineng
dc.subjectG protein-coupled receptor kinase (GRK)eng
dc.subjectinteractomeeng
dc.subjectG protein-coupled receptor kinase interacting protein 2 (GIT2)eng
dc.subjectataxia telangiectasia mutated (ATM)eng
dc.subjectclock proteinseng
dc.subjectenergy metabolismeng
dc.subject.ddc570 Biologienone
dc.titleG Protein-Coupled Receptor Systems as Crucial Regulators of DNA Damage Response Processesnone
dc.typearticle
dc.identifier.urnurn:nbn:de:kobv:11-110-18452/26022-6
dc.identifier.doi10.3390/ijms19102919none
dc.identifier.doihttp://dx.doi.org/10.18452/25327
dc.type.versionpublishedVersionnone
local.edoc.container-titleInternational journal of molecular sciencesnone
local.edoc.pages30none
local.edoc.type-nameZeitschriftenartikel
local.edoc.institutionLebenswissenschaftliche Fakultätnone
local.edoc.container-typeperiodical
local.edoc.container-type-nameZeitschrift
local.edoc.container-publisher-nameMolecular Diversity Preservation Internationalnone
local.edoc.container-publisher-placeBaselnone
local.edoc.container-volume19none
local.edoc.container-issue10none
dc.description.versionPeer Reviewednone
local.edoc.container-articlenumber2919none
dc.identifier.eissn1422-0067

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