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2021-12-22Zeitschriftenartikel DOI: 10.18452/26142
Caldendrin and myosin V regulate synaptic spine apparatus localization via ER stabilization in dendritic spines
dc.contributor.authorKonietzny, Anja
dc.contributor.authorGrendel, Jasper
dc.contributor.authorKádek, Alan
dc.contributor.authorBucher, Michael
dc.contributor.authorHan, Yuhao
dc.contributor.authorHertrich, Nathalie
dc.contributor.authorDekkers, Dick
dc.contributor.authorDemmers, Jeroen
dc.contributor.authorGrünewald, Kay
dc.contributor.authorUetrecht, Charlotte
dc.contributor.authorMikhaylova, Marina
dc.date.accessioned2023-02-28T08:45:32Z
dc.date.available2023-02-28T08:45:32Z
dc.date.issued2021-12-22none
dc.identifier.urihttp://edoc.hu-berlin.de/18452/26803
dc.description.abstractExcitatory synapses of principal hippocampal neurons are frequently located on dendritic spines. The dynamic strengthening or weakening of individual inputs results in structural and molecular diversity of dendritic spines. Active spines with large calcium ion (Ca2+) transients are frequently invaded by a single protrusion from the endoplasmic reticulum (ER), which is dynamically transported into spines via the actin-based motor myosin V. An increase in synaptic strength correlates with stable anchoring of the ER, followed by the formation of an organelle referred to as the spine apparatus. Here, we show that myosin V binds the Ca2+ sensor caldendrin, a brain-specific homolog of the well-known myosin V interactor calmodulin. While calmodulin is an essential activator of myosin V motor function, we found that caldendrin acts as an inhibitor of processive myosin V movement. In mouse and rat hippocampal neurons, caldendrin regulates spine apparatus localization to a subset of dendritic spines through a myosin V-dependent pathway. We propose that caldendrin transforms myosin into a stationary F-actin tether that enables the localization of ER tubules and formation of the spine apparatus in dendritic spines.eng
dc.language.isoengnone
dc.publisherHumboldt-Universität zu Berlin
dc.rights(CC BY-NC-ND 4.0) Attribution-NonCommercial-NoDerivatives 4.0 Internationalger
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/4.0/
dc.subjectcaldendrineng
dc.subjectendoplasmic reticulumeng
dc.subjectmyosineng
dc.subjectspine apparatuseng
dc.subjectsynapseng
dc.subject.ddc540 Chemie und zugeordnete Wissenschaftennone
dc.titleCaldendrin and myosin V regulate synaptic spine apparatus localization via ER stabilization in dendritic spinesnone
dc.typearticle
dc.identifier.urnurn:nbn:de:kobv:11-110-18452/26803-6
dc.identifier.doihttp://dx.doi.org/10.18452/26142
dc.type.versionpublishedVersionnone
local.edoc.pages24none
local.edoc.type-nameZeitschriftenartikel
local.edoc.container-typeperiodical
local.edoc.container-type-nameZeitschrift
dc.description.versionPeer Reviewednone
dc.identifier.eissn1460-2075
dcterms.bibliographicCitation.doi10.15252/embj.2020106523
dcterms.bibliographicCitation.journaltitleThe EMBO journalnone
dcterms.bibliographicCitation.volume41none
dcterms.bibliographicCitation.issue4none
dcterms.bibliographicCitation.articlenumbere106523none
dcterms.bibliographicCitation.originalpublishernameWileynone
dcterms.bibliographicCitation.originalpublisherplaceHoboken, NJ [u.a.]none
bua.departmentLebenswissenschaftliche Fakultätnone

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