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2022-03-23Zeitschriftenartikel DOI: 10.18452/26456
Aryl Hydrocarbon Receptor-Dependent and -Independent Pathways Mediate Curcumin Anti-Aging Effects
dc.contributor.authorBrinkmann, Vanessa
dc.contributor.authorRomeo, Margherita
dc.contributor.authorLarigot, Lucie
dc.contributor.authorHemmers, Anne
dc.contributor.authorTschage, Lisa
dc.contributor.authorKleinjohann, Jennifer
dc.contributor.authorSchiavi, Alfonso
dc.contributor.authorSteinwachs, Swantje
dc.contributor.authorEsser, Charlotte
dc.contributor.authorMenzel, Ralph
dc.contributor.authorGiani Tagliabue, Sara
dc.contributor.authorBonati, Laura
dc.contributor.authorCox, Fiona
dc.contributor.authorAle-Agha, Niloofar
dc.contributor.authorJakobs, Philipp
dc.contributor.authorAltschmied, Joachim
dc.contributor.authorHaendeler, Judith
dc.contributor.authorCoumoul, Xavier
dc.contributor.authorVentura, Natascia
dc.date.accessioned2023-05-02T08:46:18Z
dc.date.available2023-05-02T08:46:18Z
dc.date.issued2022-03-23none
dc.date.updated2022-04-26T11:45:59Z
dc.identifier.urihttp://edoc.hu-berlin.de/18452/27135
dc.description.abstractThe aryl hydrocarbon receptor (AhR) is a ligand-activated transcription factor whose activity can be modulated by polyphenols, such as curcumin. AhR and curcumin have evolutionarily conserved effects on aging. Here, we investigated whether and how the AhR mediates the anti-aging effects of curcumin across species. Using a combination of in vivo, in vitro, and in silico analyses, we demonstrated that curcumin has AhR-dependent or -independent effects in a context-specific manner. We found that in Caenorhabditis elegans, AhR mediates curcumin-induced lifespan extension, most likely through a ligand-independent inhibitory mechanism related to its antioxidant activity. Curcumin also showed AhR-independent anti-aging activities, such as protection against aggregation-prone proteins and oxidative stress in C. elegans and promotion of the migratory capacity of human primary endothelial cells. These AhR-independent effects are largely mediated by the Nrf2/SKN-1 pathway.eng
dc.language.isoengnone
dc.publisherHumboldt-Universität zu Berlin
dc.rights(CC BY 4.0) Attribution 4.0 Internationalger
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/
dc.subjectaryl hydrocarbon receptoreng
dc.subjectcurcumineng
dc.subjectoxidative stresseng
dc.subjectCaenorhabditis eleganseng
dc.subjectmiceeng
dc.subjectendothelial cellseng
dc.subjectin vivoeng
dc.subjectin vitroeng
dc.subjectin silicoeng
dc.subject.ddc610 Medizin und Gesundheitnone
dc.titleAryl Hydrocarbon Receptor-Dependent and -Independent Pathways Mediate Curcumin Anti-Aging Effectsnone
dc.typearticle
dc.identifier.urnurn:nbn:de:kobv:11-110-18452/27135-1
dc.identifier.doihttp://dx.doi.org/10.18452/26456
dc.type.versionpublishedVersionnone
local.edoc.pages30none
local.edoc.type-nameZeitschriftenartikel
local.edoc.container-typeperiodical
local.edoc.container-type-nameZeitschrift
dc.description.versionPeer Reviewednone
dc.identifier.eissn2076-3921
dcterms.bibliographicCitation.doi10.3390/antiox11040613none
dcterms.bibliographicCitation.journaltitleAntioxidantsnone
dcterms.bibliographicCitation.volume11none
dcterms.bibliographicCitation.issue4none
dcterms.bibliographicCitation.articlenumber613none
dcterms.bibliographicCitation.originalpublishernameMDPInone
dcterms.bibliographicCitation.originalpublisherplaceBaselnone
bua.departmentLebenswissenschaftliche Fakultätnone

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