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2023-08-21Zeitschriftenartikel DOI: 10.18452/28551
Moving on: How malaria parasites exit the liver
dc.contributor.authorScheiner, Mattea
dc.contributor.authorBurda, Paul-Christian
dc.contributor.authorIngmundson, Alyssa
dc.date.accessioned2024-04-22T15:42:53Z
dc.date.available2024-04-22T15:42:53Z
dc.date.issued2023-08-21none
dc.date.updated2024-04-16T08:22:01Z
dc.identifier.issn0950-382X
dc.identifier.urihttp://edoc.hu-berlin.de/18452/29186
dc.description.abstractAn essential step in the life cycle of malaria parasites is their egress from hepatocytes, which enables the transition from the asymptomatic liver stage to the pathogenic blood stage of infection. To exit the liver, Plasmodium parasites first disrupt the parasitophorous vacuole membrane that surrounds them during their intracellular replication. Subsequently, parasite-filled structures called merosomes emerge from the infected cell. Shrouded by host plasma membrane, like in a Trojan horse, parasites enter the vasculature undetected by the host immune system and travel to the lung where merosomes rupture, parasites are released, and the blood infection stage begins. This complex, multi-step process must be carefully orchestrated by the parasite and requires extensive manipulation of the infected host cell. This review aims to outline the known signaling pathways that trigger exit, highlight Plasmodium proteins that contribute to the release of liver-stage merozoites, and summarize the accompanying changes to the hepatic host cell.eng
dc.description.sponsorshipDeutsche Forschungsgemeinschaft SPP2225
dc.language.isoengnone
dc.publisherHumboldt-Universität zu Berlin
dc.rights(CC BY 4.0) Attribution 4.0 Internationalger
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/
dc.subjectegresseng
dc.subjectliver stageeng
dc.subjectmalariaeng
dc.subjectmerosome formationeng
dc.subjectPlasmodiumeng
dc.subjectPVM ruptureeng
dc.subject.ddc570 Biologienone
dc.titleMoving on: How malaria parasites exit the livernone
dc.typearticle
dc.identifier.urnurn:nbn:de:kobv:11-110-18452/29186-2
dc.identifier.doihttp://dx.doi.org/10.18452/28551
dc.type.versionpublishedVersionnone
local.edoc.pages13none
local.edoc.type-nameZeitschriftenartikel
local.edoc.container-typeperiodical
local.edoc.container-type-nameZeitschrift
dc.description.versionPeer Reviewednone
dc.identifier.eissn1365-2958
dcterms.bibliographicCitation.doi10.1111/mmi.15141
dcterms.bibliographicCitation.journaltitleMolecular microbiologynone
dcterms.bibliographicCitation.volume121none
dcterms.bibliographicCitation.issue3none
dcterms.bibliographicCitation.originalpublishernameWiley-Blackwellnone
dcterms.bibliographicCitation.originalpublisherplaceOxford [u.a.]none
dcterms.bibliographicCitation.pagestart328none
dcterms.bibliographicCitation.pageend340none
bua.departmentLebenswissenschaftliche Fakultätnone

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